The research programs of CMCT Faculty have the unifying theme: to define host responses to environmental toxicants and to dissect the influence of genetic background, developmental age and diet on these responses.
It should be noted that some training faculty may fit into more than one of the 4 defined areas which facilitates collaborative interactions and interdisciplinary research and training.
Thomas Brenna, Ph.D., Professor of Pediatrics at Dell Med; Professor of Chemistry and of Human Nutrition in the College of Natural Sciences, UT Austin. Research interests: nutrition, metabolism, genetics, chemical analysis, ad food chemistry of fatty acids and lipids in neurocognitive development and in disease; development of isotope ratio mass spectrometry and molecular mass spectrometry instrumentation and methods for lipid analysis and anti-doping drug testing; role of fats in ecology and human evolution.
Kevin Dalby, Ph.D., Professor of Medicinal Chemistry; Potential for cancer treatment through the targeting of protein kinases by utilizing novel efforts in chemical biology.
Jaquelin Dudley, Ph.D., Professor of Molecular Biosciences, UT Austin, Retroviruses, such as human immunodeficiency virus (HIV); breast cancer; mouse mammary tumor virus (MMTV) as a mouse model for HIV.
Lauren Ehrlich, Ph.D., Associate Professor of Molecular Biosciences, UT Austin, T cell development; thymocyte localization, thymocyte stromal interactions; thymic lymphomagenesis.
John DiGiovanni, Ph.D., Professor of Pharmacology & Toxicology and Coulter R. Sublett Chair, Identification of critical targets for both the initiation and promotion stages of carcinogenesis.
Ning (Jenny) Jiang, Ph.D., Assistant Professor of Biomedical Engineering, UT Austin, technology development in systems immunology and immune engineering and applying them to study the immune system development, infection and cancer immunology and immunotherapy.
Sean M. Kerwin, Ph.D.,Professor, Department of Chemistry & Biochemistry, Texas State University; Covalent modification of DNA by small molecules including carcinogens, natural products, and drugs; Non-canonical DNA structures as sites for DNA damage and drug interaction; synthesis of natural products and analogs to probe molecular mechanisms related to cancer prevention and treatment.
Dawit Kidane, Ph.D., Assistant Professor of Pharmacology and Toxicology; Cancer biology; DNA repair and genomic instability; Infection-mediated inflammation and cancer, DNA damage response in preeclampsia; Screening DNA repair genes as a novel biomarkers for predicting preeclampsia.
Kevin McBride, Ph.D., Assistant Professor, UT MD Anderson Cancer Center, Science Park-Research Division; DNA hypermutation and recombination, error prone DNA repair, single cell mutation analysis.
Edward Mills, Ph.D., Associate Professor of Pharmacology and Toxicology; Understanding how mitochondria talk to other cellular components and how mitochondria participate in the pharmacologic and toxic actions of chemicals and in disease processes.
Stephano Tiziani, Ph.D., Assistant Professor of Nutrition; Cancer metabolism, leukemia, metabolomics, pediatric diseases.
Karen M. Vasquez, Ph.D., Professor of Pharmacology & Toxicology and Coulter R. Sublett Fellow; Elucidate the molecular mechanisms of DNA damage recognition by DNA repair and recombination pathways, Develop triplex technology to modify mammalian gene structure and function, Study the role of DNA structure in genomic instability and mutagenesis.