The research programs of CMCT Faculty have the unifying theme: to define host responses to environmental toxicants and to dissect the influence of genetic background, developmental age and diet on these responses.
It should be noted that some training faculty may fit into more than one of the 4 defined areas which facilitates collaborative interactions and interdisciplinary research and training.
Shawn B. Bratton, Ph.D., Associate Professor, UT MD Anderson Cancer Center, Science Park-Research Division; Basic mechanisms of apoptosis.
Richard L. Corsi, Ph.D., Professor, Department of Civil, Architectural and Environmental Engineering;Analysis and control of fugitive contaminant emissions from industrial wastewater and process streams; cross-media contaminant transport; atmospheric transport modeling; indoor air quality.
Walter Fast, Ph.D., Associate Professor of Medicinal Chemistry; Enzymology of Arginine Modification and Bacterial Communication. Enzyme Mechanisms, Inhibitor Design, Protein Engineering.
David G. Johnson, Ph.D., Professor, UT MD Anderson Cancer Center, Science Park-Research Division; E2F transcription factors, cell cycle, tumor suppressor genes, oncogenes.
Sean M. Kerwin, Ph.D., Professor, Department of Chemistry & Biochemistry, Texas State University; Covalent modification of DNA by small molecules including carcinogens, natural products, and drugs; Non-canonical DNA structures as sites for DNA damage and drug interaction; synthesis of natural products and analogs to probe molecular mechanisms related to cancer prevention and treatment.
Edward Mills, Ph.D., Associate Professor of Pharmacology and Toxicology; Understanding how mitochondria talk to other cellular components and how mitochondria participate in the pharmacologic and toxic actions of chemicals and in disease processes.
Som Mukhopadhyay, Ph.D., The regulation of manganese (Mn) homeostasis in mammalian cells and in the pathobiology of Mn-induced neurotoxicity. Specifically, evaluating the export of Mn via the Golgi followed by secretion as the primary route of Mn efflux and detoxification in mammalian cells.
John H. Richburg, Ph.D., Professor of Pharmacology and Toxicology; Mechanisms Regulating Apoptosis/Male Reproductive Toxicology. Peripubertal sensitivity to testicular toxicants.