Publications

(2017)

31. Synthesis and bioactivity of bis-steroidal pyrazine 23-deoxy-25-epi ritterostatin GN1N. Kumar, RN.; Lee, S.* Steroids 126, 74-78.

 30. Synthesis, structure, and biological evaluation of a platinum-carbazole conjugate. Cheun Y, Koag MC, Naguib YW, Ouzon-Shubeita H, Cui Z, Pakotiprapha D, Lee S. Chem Biol Drug Des. 2017  doi: 10.1111/cbdd.13062. [Epub ahead of print]

29. Synthesis of 23-deoxy-25-epi north unit of cephalostatin 1 via reductive and oxidative modifications of hecogenin acetate. Kumar, N.; Lee, S.*  Steroids. 2017, 118, 68-75

(2016)

28. cis-Diammine[3-(3-chloro-7-methoxy-9,10-dihydroacridin-9-ylideneamino)propan-1-aminej2 N,N0]platinum(II) dinitrate. Cheun, Y.; Lee, S*. IUCrData (2016). 1, x160481.

(2015)

27. N7 methylation alters hydrogen-bonding patterns of guanine in duplex DNA. Kou, Y.; Koag, M; Lee, S.* J. Am. Chem. Soc. 2015, 137, 14067-14070.

(2014)

26. Structural basis for the inefficient nucleotide incorporation opposite cisplatin-DNA lesion by human DNA polymerase β. Koag, M.; Lai, L. ; Lee, S.*J. Biol. Chem. 2014, 289, 31341-31348.      

25. The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β. Koag, M.; Nam, K.*; Lee, S.*Nucleic Acids Res. 2014, 42, 11233-11245.      

24. Transition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanine. Koag, M.; Kou, Y.; Ouzon, H.; Lee, S.Nucleic Acids Res. 2014, 42, 8755-8766.      

 

23. Streamlining bottom-up protein identification based on selective UVPD of chromophore-tagged histidine- and tyrosine-containing peptides. Aponte, J.; Vasicek, L.; Waminathan, J.; Xu, H.; Koag, M.; Lee, S.; Brodbelt, J. S.*Anal. Chem. 2014, 86, 6237-6244.     

22. Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase β.Koag, M.; Lee, S.* J. Am. Chem. Soc. 2014, 136, 5709-5721. (Recommended for F1000Prime)  

21. Structural basis for the promutagenicity of 8-bromoguanine. Koag, M.; Min, K.§; Lee, S. *J. Biol. Chem. 2014, 289, 6289-6298.

  

(2013)

20. Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4. Koag, M.; Cheun, Y.; Kou, Y.; Ouzon-Shubeita, H.; Min, K.§; Monzingo, A. F.; Lee, S.* Steroids, 2013, 79, 938-944.

19. Unexpected opening of steroidal E-ring during hypoiodite-mediated oxidation. Kou, Y.; Lee, S.*. Tetrahedron Lett. 2013, 54, 4106-4109. 

 

18. Synthesis of C17-OH-north unit of ritterazine G via “Red-Ox” modifications of hecogenin acetate. Cheun, Y.; Kou, Y.; Stevenson, B.; Kim, H.; Koag, M.; Lee, S.* Steroids, 2013, 78, 639-643.

17. Synthesis of 14′,15′-dehydro-ritterazine Y via reductive and oxidative functionalizations of hecogenin acetate. Kou, Y.; Cheun, Y.; Koag, M.; Lee, S.* Steroids, 2013, 78, 304-311.   

(2012)

16. Application of hypoiodite-mediated aminyl radical cyclization to synthesis of solasodine acetate. Kou, Y.; Cheun, Y.; Koag, M.; Shin, A§.; Lee, S.* Steroids, 2012, 77, 1069-1074.   

15. Transetherification-mediated E-ring opening and stereoselective “Red-Ox” modification of furostan.Cheun, Y.; Koag, M.; Kou, Y.; Warnken, Z.;  Lee, S.* Steroids 2012, 77, 276-281.   

(2011)

14. Discovery of hypoiodite-mediated aminyl radical cyclization lacking a nitrogen radical-stabilizing group: Application to synthesis of an oxazaspiroketal-containing cephalostatin analog.Koag, M.; Lee, S.* Org. Lett., 2011, 13, 4766–4769.  

(2010)

13. Structure of Escherichia coli 3-methyladenine DNA glycosylase AlkA bound to  undamaged DNA. Bowman, B. R.; Lee, S.; Wang, S.; Verdine, G. L.*  J. Biol. Chem. 2010, 285, 35783-791.   

(2009)

12. Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase. Lee, S.; Verdine, G. L.* Proc. Natl. Acad. Sci. USA 2009, 106, 18497.  

11. Chemistry of trisdecacyclic pyrazine antineoplastics: The cephalostatins and ritterazines. Lee, S.; LaCour, T. G.; Fuchs, P. L.* Chem. Rev. 2009, 109, 2275.       

10. Synthesis of C14,15-dihydro-25-epi north unit of cephalostatin 1 via redox modifications of hecogenin acetate. Lee, S.*; Jamieson, D.; Fuchs, P. L.* Org. Lett. 2009, 11, 5.

(2008)

9. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. Lee, S.; Bowman, R. B.; Ueno, Y.; Verdine, G. L.* J. Am. Chem. Soc. 2008, 130, 11570.   8. Trapping and structural elucidation of a very advanced intermediate in the lesion-extrusion pathway of hOGG1 (highlighted in Nat. Chem. Biol. 2008, 4, 395)                   Lee, S.; Radom, C. T. Verdine, G. L.* J. Am. Chem. Soc. 2008, 130, 7784. 

 7. Structure of the Escherichia coli DNA glycosylase AlkA bound to the ends of duplex DNA: A system for the facile structure determination of lesion-containing DNA.Bowman, B. R§.; Lee, S. § (§equal authorship); Verdine, G. L.* Structure 2008, 16, 1166.   

(2007)

6. A Concise synthesis of 4′-F nucleic acids. Lee, S.; Utammapinat, C.; Verdine, G. L.* Org. Lett. 2007, 9, 5007.                                                                                            

(2006)

5. In situ nitrosonium ion generation. Oximinylation of enol ethers from steroidal spiroketals. Introduction of C23-OH in cephalostatin intermediates. Lee, S.; Fuchs, P. L.* Can. J. Chem. 2006, 84, 1442.

(2004)

4. An efficient C-H oxidation protocol for the α-hydroxylation of cyclic steroidal ethers. Highly efficient, regio- and stereoselective oxyfunctionalization of steroids by Cr[VI]. Lee, S.; Fuchs, P. L.* Org. Lett. 2004, 6, 1437.   

(2002)

3. Chemospecific chromium[VI] catalyzed oxidation of C-H bonds at -40 oC. Lee, S.; Fuchs, P. L.* J. Am. Chem. Soc. 2002, 124, 13978.

2. The first total synthesis of ritterazine M. Lee, S.; Fuchs, P. L.* Org. Lett. 2002, 4, 317..                               

1. Redox functionalization of steroid spiroketals. Structure correction of ritterazine M. Lee, S.; LaCour, T. G.; Lantrip, D. A.; Fuchs, P. L.* Org. Lett. 2002, 4, 313. 

 

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