2016 – Present

  1. Besandre, R.; Liu, H.-w. “Biochemical Basis of Vosevi, a New Treatment for Hepatitis C.” Biochemistry, in press.
  2. Lin, G.-M.; Romo, A. J.; Liem, P. H.; Chen, Z.; Liu, H.-w. “Identification and Interrogation of the Herbicidin Biosynthetic Gene Cluster: First Insight into the Biosynthesis of a Rare Undecose Nucleoside Antibiotic.” J. Am. Chem. Soc. 2017, 139, in press.
  3. Kim, H. J.; Liu, Y.-n.; McCarty, R. M.; Liu, H.-w. “Biochemical Characterization and Stereochemical Analysis of Reactions Catalyzed by GenK, a Cobalamin-Dependent Radical SAM Methyltransferase Involved in Gentamicin Biosynthesis.” J. Am. Chem. Soc. 2017, 139, in press.
  4. Ruszczycky, M. W.; Liu, H.-w. “The Surprising History of an Antioxidant.” Nature 2017, 551, 37-38.
  5. Ruszczycky, M. W.; Liu, H.-w. “Steady-State Kinetic Isotope Effects from Net Rate Constants and Enzyme Intermediate Concentrations.” Meth. Enzymol. 2017, 596, 459-499.
  6. Jeon, B.-s.; Ruszczycky, M. W.; Russell, W. K.; Lin, G.-M.; Kim, N.; Choi, S.-h.; Wang, S-A.; Liu, Y.-n.; Patrick, J.; Russell, D. H.; Liu, H.-w. “Mechanistic Studies of the SpnF-Catalyzed [4+2]-Cycloaddition in the Biosynthesis of Spinosyn A.” Proc. Natl. Acad. Sci. USA 2017, 114, 10408-10413.
  7. Thibodeaux, C. J.; Liu, H.-w. “The Type II Isopentenyl Diphosphate: Dimethylallyl Diphos-phate Isomerase (IDI-2): A Model for Acid/Base Chemistry in Flavoenzyme Catalysis.” Arch. Biochem. Biophys. 2017, 632, 47-58.
  8. Zhang, Q.; Li, H.; Yu, L.; Sun, Y.; Zhu, Y.; Zhu, H.; Zhang, L.; Li, S.-M.; Shen, Y.; Tian, C.; Li, A.; Liu, H.-w.; Zhang, C. “Characterization of the Flavoenzyme XiaK as an N-Hydroxylase and Implications in Indolosesquiterpene Diversification.” Chem. Sci. 2017, 8, 5067-5077.
  9. Ko, Y.; Wang, S.-A.; Ogasawara, Y.; Ruszczycky, M. W.; Liu, H.-w. “Characterization of Enzyme-catalyzed Pyrazolopyrimidine Formation i nteh Biosynthesis of Formycin A.” Org. Lett. 2017, 19, 1426-1429.
  10. Jeon, B.-s.; Wang, S.-A.; Ruszczycky, M. W.; Liu, H.-w. “Natural [4+2]-Cyclases.” Chem. Review. 2017, 117, 5367-5388.
  11. Bridwell-Rabb, J.; Zhong, A.; Drennan, C. L.; Liu, H.-w. “A B12-dependent Radical SAM Enzyme Involved in Oxetanocin A Biosynthesis.” Nature 2017, 544, 322-326.
  12. Lin, C.-I.; McCarty, R. M.; Liu, H.-w. “Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems.” Angew Chem. Int. Ed. 2017, 56, 3446-3489.
  13. Bridwell-Rabb, J.; Kang, G.; Zhong, A.; Liu, H.-w.; Drennan, C. L. “An HD-Domain Phosphohydrolase Active Site Tailored for Oxetanocin-A Biosynthesis.” Proc. Natl. Acad. Sci. USA. 2016, 113, 13750-13755.
  14. Lin, G.-M.; Sun, H. G.; Liu, H.-w. “Study of the Uridine 5’-Monophosphate (UDP)-Galactopyranose Mutase Using UDP-5-Fluoro-Galactopyransoe As a Probe: Incubation Results and Mechanistic Implications.” Org. Lett. 2016, 18, 3438-3441.
  15. Ushimaru, R.; Lin, C.-I.; Sasaki, E.; Liu, H.-w. “Characterization of Enzymes Catalyzing Transformations of Cysteine S-Conjugated Intermediates in the Lincosamide Biosynthesis Pathway.” ChemBioChem 2016, 17, 1606-1611.
  16. Patel, A.; Chen, Z.; Yang, Z.; Gutierrez, O.; Houk, K. N.; Liu, H.-w.; Singleton, D. A. “Dynamically Complex Enzyme-catalyzed [6+4] and [4+2] Cycloadditions in the Biosyn-thesis of Spinosyn A.” J. Am. Chem. Soc. 2016, 138, 3631-3634.
  17. He, W.; Liu, M.; Li X.; Zhang, X.; Abdel-Mageed, W. M.; Li L.; Wang, W.; Zhang, J.; Han, J.; Dai, H.; Quinn, R. J.; Liu, H.-w.; Luo, H.; Liu, X.; Zhang, L. “Fungal Biotransformation of Tanshinone Results in [4+2] Cycloaddition with Sorbicillinol: Evidence for Enzyme Catalysis and Increased Antibacterial Activity.” Appl. Microbiol. Biotechnol. 2016, 2016, 1-9.
  18. Jackson, D. R.; Yu, X.; Wang, G.; Calveras, J.; Patel, A. B.; Calveras, J.; Barajas, J. F.; Sasaki, E.; Metsä-Ketelä, M.; Liu, H.-w.; Rohr, J.; Tsai, S.-C. “Insights Into Complex Oxidation During BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE.” ACS Chem. Biol. 2016, 11, 1137-1147
  19. Kim, H. J.; LeVieux, J.; Yeh, Y.-C.; Liu, H.-w. “C3′-Deoxygenation of Paromamine Catalyzed by a Radical SAM Enzyme: Characterization of AprD4 and Its Reductase Partner AprD3.” Angew. Chem. Int. Ed. 2016, 55, 3724-3728.