Arborizing Fiberoptic Microneedle Device for Photo-thermo-chemotherapy of Malignant Glioma
The goal of this project is to develop a superior convective-enhanced delivery (CED) treatment for malignant gliomas (MGs), in which a chemotherapeutic drug (carboplatin) is broadly and uniformly delivered with a novel medical device to primary tumors and infiltrative cells (extending >2 cm).
Bio-Mechano-Optic Stimulation and Sensing (BMOSS)
BMOSS is a technology currently under development in the Medical Device Lab. We previously demonstrated the use of mechanical deformation for reducing tissue light scattering and increasing optical penetration depth.
Bone Scaffolds for Heat Shock Protein-Induced Regeneration and Healing
The ultimate goal of this project is to develop a superior bone scaffold through stress conditioning and HSP delivery with the capability to enhance wound healing and bone regeneration in vivo.
Development and Manufacturing of Fiberoptic Microneedle Devices for Cosmetic and Cancer Treatments
Our goals are to: 1) manufacture prototype parallel arrays of FMDs for laser fat removal, and, 2) demonstrate the superior capabilities of FMDs vs. conventional laser lipolysis methods.
Optical Molecular Tomography for Regenerative Medicine
The overall goal of this project is to develop a first-of-its-kind multi-probe, multi-modal optical molecular tomography (OMT) system for regenerative medicine and to demonstrate its utility in visualizing the real-time development of bioengineered blood vessels, both in bioreactors and after implantation into living animals.
FIBEROPTIC MICRONEEDLE DEVICE FOR COMBINED LIGHT AND NANOMEDICINE DELIVERY: MIMICKING NATURE’S DESIGN OF A MOSQUITO
Sponsor: NSF: CBET: BME: 0933571
Performance Period: 8/1/09-7/31/12
PI: Chris Rylander, co-PIs: Nichole Rylander and Yong Xu
FIBEROPTIC MICRONEEDLE DEVICE FOR NANOPARTICLE-ENHANCED PHOTOTHERMAL THERAPY OF AGGRESSIVE, INFILTRATIVE BLADDER CANCER
Sponsor: NIH: NCI: R21 CA156078
Performance Period: 1/1/11-12/31/12
PI: Chris Rylander, co-PIs: M. Nichole Rylander, John Robertson, and David Grant
WORKSHOP ON BIOTRANSPORT EDUCATION DURING SUMMER BIOENGINEERING CONFERENCES, FARMINGTON, PA, JUNE 22-25, 2011 AND SUMMER 2012
Sponsor: NSF: CBET: BME: 1127262
Performance Period: 5/1/11-4/30/13
PI: Rupak Banerjee, co-PIs: Ram Devireddy and Chris Rylander