Current Projects

  • Developing PKC epsilon inhibitors to reduce chronic pain, alcohol drinking, and anxiety.
  • Identifying drug targets in PKC epsilon signaling pathways using ATP analog-sensitive kinase technology.
  • Transcriptional profiling to repurpose drugs for treating addiction.
  • Identifying neuropeptide circuits in the extended amygdala that regulate anxiety, fear and excessive alcohol consumption.
  • Identifying drug targets with neuroinflammatory pathways activated by chronic alcohol exposure.
CRF neurons of the central amygdala differentially regulate fear and anxiety through the release of GABA and different neuropeptides (Pomrenze et al, Cell Reports 2019).