Selected Publications:

Pomrenze MB, Giovanetti SM, Maiya R, Gordon AG, Kreeger LJ, Messing RO. Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRFNeurons in Anxiety and Fear Learning. Cell Rep. 2019 Oct 1;29(1):13-21.e4. doi: 10.1016/j.celrep.2019.08.083. PubMed PMID: 31577943

Wang J, Blasio A, Chapman HL, Doebelin C, Liaw V, Kuryatov A, Giovanetti SM, Lindstrom J, Lin L, Cameron MD, Kamenecka TM, Pomrenze MB, Messing RO. Promoting activity of (α4)(3)(β2)(2) nicotinic cholinergic receptors reduces ethanol consumption. Neuropsychopharmacology. 2019 Aug 8. doi: 10.1038/s41386-019-0475-8. PubMed PMID: 31394567.

de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 2019 Mar 18;10(1):1238. doi: 10.1038/s41467-019-09183-0. PubMed PMID: 30886240

Pomrenze MB, Tovar-Diaz J, Blasio A, Maiya R, Giovanetti SM, Lei K, Morikawa H, Hopf FW, Messing RO. A Corticotropin releasing factor network in the extended amygdala for anxiety. J Neurosci 2018 Dec 10. pii: 2143-18. doi: 10.1523/JNEUROSCI.2143-18.2018. PubMed PMID: 30530860.

Warden AS, Azzam MM, DaCosta A, Mason S, Blednov YA, Messing RO, Dayne Mayfield R, Adron Harris R. Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice. Brain Behav Immun. 2018 Dec 11. pii: S0889-1591(18)30386-6. doi: 10.1016/j.bbi.2018.12.004. PubMed PMID: 30550931.

Warden AS, Azzam M, DaCosta A, Mason S, Blednov YA, Messing RO, Mayfield RD, Harris RA. Toll-like receptor 3 dynamics in female C57BL/6J mice: Regulation of alcohol intake. Brain Behav Immun. 2018 Dec 11. pii: S0889-1591(18)30387-8. doi: 10.1016/j.bbi.2018.12.006.  PubMed PMID: 30550930.

YA, Da Costa AJ, Tarbox T, Ponomareva O,Messing RO, Harris RA. Apremilast alters behavioral responses to ethanol in mice: I. Reduced consumption and preference. Alcohol Clin Exp Res. 42(5):926-938, 2018. PMCID: PMC5915912.

Blednov YA, Da Costa AJ, Harris RA, Messing RO. Apremilast alters behavioral responses to ethanol in mice: II. Increased sedation, intoxication, and reduced acute functional tolerance. Alcohol Clin Exp Res. 42(5):939-951, 2018. PMCID: PMC5916327.

Blasio A, Wang J, Wang D, Varodayan FP, Pomrenze MB, Miller J, Lee AM, McMahon T, Gyawali S, Wang HY, Roberto M, McHardy S, Pleiss MA, Messing RO. Novel small-molecule inhibitors of protein kinase C epsilon reduce ethanol consumption in mice. Biol Psychiatry. 84(3):193-201, 2018. PMCID: PMC5984071.

Maiya R, McMahon T, Wang D, Kanter B, Gandhi D, Chapman HL, Miller J, Messing RO. Selective chemical genetic inhibition of protein kinase C epsilon reduces ethanol consumption in mice. Neuropharmacology. 107:40-8. 2016.  PMCID: PMC4912951.

Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO. A transgenic rat for investigating the anatomy and function of corticotrophin releasing factor circuits. Front Neurosci. 9:487, 2015. PMCID: PMC4689854.

Maiya R, Mangieri RA, Morrisett RA, Heberlein U, Messing RO. A selective role for Lmo4 in cue-reward learning.  J Neurosci. 35(26):9638-47, 2015.  PMCID: PMC4589569.

Trudell JR, Messing RO, Mayfield J, Harris RA. Alcohol dependence: molecular and behavioral evidence. Trends Pharmacol. Sci. 35(7):317-323, 2014. PMCID: PMC4089033.

Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 16(8):1094-1100, 2013. PMCID: PMC3939030.

Lee AM, Kanter BR, Wang D, Lim JP, Zou ME, Qiu C, McMahon T, Dadgar J, Fischbach-Weiss SC, Messing RO. Prkcz null mice show normal learning and memory. Nature. 493:416-419, 2013. PMCID: PMC3548047.

Lee AM and Messing RO. Protein kinase C epsilon modulates nicotine consumption and reward signals in the nucleus accumbens. Proc. Natl. Acad. Sci USA. 108:16080-16085, 2011. PMCID: PMC3179040.

 All Publications: