Our lab focuses on brain-behavior relationships during adolescence and young adulthood, specifically as they relate to the development of affective disorders and alcohol/substance use disorders.  Current longitudinal studies are using clinical/behavioral phenotyping, structural and functional magnetic resonance imaging, and genetic techniques, to investigate the onset and early disease progression in bipolar disorder and alcohol  and cannabis use disorders and the interactions between these conditions. We focus on individual differences, including directly investigating sensitivity to alcohol and stress with alcohol and stress challenge laboratory sessions, and interactions with early life stress to better understand the role(s) of these factors on clinical outcomes to inform early interventions.