The longstanding focus of my research program is to decipher the molecular and cellular mechanisms by which exposure to environmental toxicants (e.g., phthalates) or clinical chemotherapeutic agents (e.g., cisplatin) can result in the disruption in spermatogenesis. Specifically, the unifying theme of my research program is to reveal the paracrine cellular signaling mechanisms between cells in the testis that regulate the balance between survival and death of germ cells. My internationally recognized expertise in this area is tangibly reflected by the review and book chapters listed below. It is anticipated that mechanistic insights garnered from research in the laboratory will provide foundational cellular and mechanistic insights underlying the sensitivity of the testis to environmental toxicants that can be exploited in developing strategies to prevent the long-term disruption of male fertility from exposure to these agents.
- Richburg, JH., Murphy, C., and Myers, JL (2018) The Sertoli Cell as a Target for Toxicants. In: McQueen, C. A., Comprehensive Toxicology, Third Edition. Vol. 4, pp. 64–81. Oxford: Elsevier Ltd.
- Murphy, CJ and Richburg, JH (2015). Implications of Sertoli cell induced germ cell apoptosis to testicular pathology. Spermatogenesis. 4(2): e979110. DOI: 10.4161/21565562.2014.979110.
- Richburg, JH, Dwyer, JL and Murphy, CJ (2014). “The Sertoli cell as a target for toxicants.” In: Reference Module in Biomedical Sciences, Elsevier. doi: 10.1016/B978-0-12-801238-3.02133-4.
- Boekelheide, K, Johnson, K and Richburg, JH (2005). “Sertoli Cell Toxicants.” In: Sertoli Cell Biology, Chapter 20 (eds. Skinner, MK and Griswold, MD). Elsevier Academic Press, San Diego, CA. pp.345-382.
John H. Richburg, Ph.D.
Male Fertility: Richburg Lab Research in the News
Dr. Richburg speaks with KXAN News about his research in how male fertility can be affected by environmental toxins found in everyday plastic products, and by chemotherapy in the treatment of testicular cancer (OK, a little dated now – but still fun to watch!)..