Research Projects

Paracrine Signaling Mechanisms

The broad focus of the research in the Richburg lab is to decipher the molecular and cellular mechanisms by which exposure to certain environmental (e.g., phthalate acid ester based plasticizers) or clinical chemotherapeutic agents (e.g., cisplatin) can result in disruption of male reproduction. Specifically, the unifying theme of the 4 ongoing research projects is to reveals the paracrine cellular signaling mechanisms between the Sertoli cells and germ cells of the testicular seminiferous epithelium that regulate the death (and/or survival) of germ cells by the process of apoptosis.

Project 1: MEHP-induced testicular inflammation &  germ cell apoptosis

Project 2: Deciphering mechanisms of cisplatin-induced male infertility

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Texas Pharmacy: The University of Texas at Austin College of Pharmacy