John Richburg participates on manuscript in the Journal of Clinical Investigation Insight.
(“Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice”. Journal of Clinical Investigation Insight. 3(16) e99767.)
Jorine Voss publishes manuscript in Reproduction.
(“MEHP-induced rat testicular inflammation does not exacerbate germ cell apoptosis”. Reproduction. 156 (1): 35-46. PMCID: PMC6021206)
Angela Stermer awarded American Foundation for Pharmaceutical Education (AFPE) Pre-Doctoral Award in Pharmaceutical Sciences!
Richburg Awarded New 5-year NIH Grant!
Dr. John Richburg was successfully awarded a 5 year R01 grant from the NIH/NIEHS (10/15-09/19). The focus of this research proposal is to distinguish the contribution of the innate immune system (macrophages, monocytes, neutrophils, natural killer and dendritic cells) in the loss of germ cells from the postnatal male testis after exposure to phthalates; a class of compounds used in consumer products and found ubiquitously in the environment. This work is relevant to human health as it is hypothesized that immune cell infiltration into the testis underlies the susceptibility of individuals (age and/or pre-existing inflammatory state) to phthalate-induced testicular toxicity. It is anticipated that the mechanistic insights provided from this research will be useful for predicting and preventing human reproductive health risks to this class of chemicals found broadly dispersed in the environment.