TTP is aiming to provide a centralized life science infrastructure to promote scientific interaction where translational scientist and clinicians can work collaboratively, building upon existing strength and the unique resources of the university and the State of Texas for the discovery and development of therapeutic probes. Our representative collaborators can be found here.
2. Early stage drug discovery guidance
Assay Guidance Manual: A free, best-practices online resource devoted to the successful development of robust, early-stage drug discovery assays. The manual was originally developed by Eli Lilly and Company to provide step-by-step guidance based on “tribal knowledge” from drug developers for planning and creating projects for high-throughput screening, lead optimization and early phases of regulated drug development. A series of brief audio presentations can be found in two-day workshop, click here.
Cambridge MedChem Consulting: A resource provided by a commercial sector for scientists undertaking drug discovery, categorized by Target Validation, Hit Identification, Lead Identification, Lead Optimization, ADME Properties, Pre-Clinical Toxicity, Miscellaneous, and
Reporting data from high-throughput screening of small-molecule libraries
Biophysics in drug discovery
Statistical practice in high-throughput screening
SLAS Discovery Special Issue (Volume 26 Issue 10, December 2021): Assay Guidance Manual for Drug Discovery: Robust or Go Bust
Assay Guidance Workshop for Cell-Based Assays and Lead Discovery