Publications

Burks, E.A., Yan, W., Johnson, Jr., W.H., Li, W., Schroeder, G.K., Min, C., Gerratana, B., Zhang, Y., and Whitman, C.P. (2011) Kinetic, crystallographic, and mechanistic characterization of TomN: elucidation of a function for a 4-oxalocrotonate tautomerase homologue in the tomaymycin biosynthetic pathway, Biochemistry 35, 7600-7611.

Schroeder, G.K., Johnson, Jr., W.H., Huddleston, J.P., Serrano, H., Johnson, K.A., and Whitman, C.P. (2012) Reaction of cis-3-chloroacrylic acid dehalogenase with an allene substrate, 2,3-butadienoate: hydration via an enamine, J. Am. Chem. Soc. 134, 293-304.

Huddleston, J.P., Schroeder, G.K., Johnson, K.A., and Whitman, C.P. (2012) A pre-steady-state kinetic analysis of the αY60W mutant of trans-3-chloroacrylic acid dehalogenase: implications for the mechanism of the wild type enzyme, Biochemistry 51, 9420-9435.

Whitman, C.P. (2013) Functional (Mis)Assignment in the Tomaymycin Biosynthetic Pathway In Experimental Standard Conditions of Enzyme Characterizations – Protein Structure Meets Enzyme Kinetics, Proceedings of the 5th International Beilstein Symposium, Rudesheim, Germany, Sept 12-16, 2011; M.G. Hicks, C. Kettner, Eds.; Beilstein-Institute, Frankfurt, Germany, 2013; 111-127.

Schroeder, G.K., Huddleston, J.P., Johnson, Jr., W.H., and Whitman, C.P. (2013) A mutational analysis of the active site loop residues in cis-3-chloroacrylic acid dehalogenase, Biochemistry 52, 4204-4216.

Guo, Y., Serrano, H., Poelarends, G.J., Johnson, Jr., W.H., Hackert, M.L., and Whitman, C.P. (2013) Kinetic, mutational, and structural analysis of malonate semialdehyde decarboxylase from Coryneform bacterium strain FG41: mechanistic implications for the decarboxylase and hydratase activities, Biochemistry 52, 4830-4831.

Terrell, C.R., Burks, E.A., Whitman, C.P., and Hoffman, D.W. (2013) Structural and kinetic characterization of two 4-oxalocrotonate tautomerases in Methylibium petroleiphilum strain PM1, Arch. Biochem. Biophys. 537, 113-124.

Poelarends, G.J., Serrano, H., Huddleston, J.P., Johnson, Jr., W.H., and Whitman, C.P. (2013) A mutational analysis of active site residues in trans-3-chloroacrylic acid dehalogenase, FEBS Lett. 587, 2842-2850.

Huddleston, J.P., Burks, E.A., and Whitman, C.P. (2014) Identification and characterization of new family members in the tautomerase superfamily, Arch. Biochem. Biophys. 564, 189-196.

Huddleston, J.P., Johnson, Jr., W.H., Schroeder, G.K., and Whitman, C.P. (2015) The accidental assignment of function in the tautomerase superfamily, Perspect. Sci. 4, 38-45.

Huddleston, J.P., Johnson, Jr., W.H., Schroeder, G.K., and Whitman, C.P. (2015) Reactions of Cg10062, a cis-3-chloroacrylic acid dehalogenase homologue, with acetylene and allene substrates: evidence for a hydration-dependent decarboxylation, Biochemistry 54, (in press).


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