The research programs of CMCT Faculty have the unifying theme: to define host responses to environmental toxicants and to dissect the influence of genetic background, developmental age and diet on these responses.
It should be noted that some training faculty may fit into more than one of the 4 defined areas which facilitates collaborative interactions and interdisciplinary research and training.
Mark T. Bedford, Ph.D., Professor, UT MD Anderson Cancer Center, Science Park-Research Division; Arginine methylation, WW domains, Protein-protein interactions, Gene targeting.
Sean M. Kerwin, Ph.D., Professor, Department of Chemistry & Biochemistry, Texas State University; Covalent modification of DNA by small molecules including carcinogens, natural products, and drugs; Non-canonical DNA structures as sites for DNA damage and drug interaction; synthesis of natural products and analogs to probe molecular mechanisms related to cancer prevention and treatment.
Dawit Kidane, Ph.D., Assistant Professor of Pharmacology and Toxicology; Cancer biology; DNA repair and genomic instability; Infection-mediated inflammation and cancer, DNA damage response in preeclampsia; Screening DNA repair genes as a novel biomarkers for predicting preeclampsia.
Seongmin Lee, Ph.D., Associate Professor of Chemical Biology and Medicinal Chemistry; Damage repair and enzymatic modifications of DNA and RNA, and is striving to discover potent chemotherapeutics that selectively inhibit DNA-modifying enzymes.
Kevin McBride, Ph.D., Assistant Professor, UT MD Anderson Cancer Center, Science Park-Research Division; DNA hypermutation and recombination, error prone DNA repair, single cell mutation analysis.
Karen M. Vasquez, Ph.D., Professor of Pharmacology & Toxicology and Coulter R. Sublett Fellow; Elucidate the molecular mechanisms of DNA damage recognition by DNA repair and recombination pathways, Develop triplex technology to modify mammalian gene structure and function, Study the role of DNA structure in genomic instability and mutagenesis.
Guliang Wang, Ph.D., Research Assistant Professor of Pharmacology and Toxicology, UT Austin, Understanding the effects of DNA modification and secondary structure on DNA damage/repair and genomic instability, and the cellular response to DNA damaging agents.
Richard Wood, Ph.D., Professor of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, analysis of pathways of DNA Repair, DNA polymerases, amd DNA damage tolerance.