The research programs of CMCT Faculty have the unifying theme: to define host responses to environmental toxicants and to dissect the influence of genetic background, developmental age and diet on these responses.
It should be noted that some training faculty may fit into more than one of the 4 defined areas which facilitates collaborative interactions and interdisciplinary research and training.
Shawn B. Bratton, Ph.D., Professor, UT MD Anderson Cancer Center, Science Park-Research Division; Basic mechanisms of apoptosis.
Sharon DeMorrow, Ph.D., Professor of Pharmacology and Toxicology; neurological changes associated with either acute liver failure or chronic liver disorders.
Walter Fast, Ph.D., Associate Professor of Medicinal Chemistry; Enzymology of Arginine Modification and Bacterial Communication. Enzyme Mechanisms, Inhibitor Design, Protein Engineering.
Regina Mangieri, Ph.D., Research Assistant Professor, Pharmacology and Toxicology; behavioral testing and ex vivo electrophysiology to examine how ethanol exposure and/or neuroimmune signaling pathways regulate cellular physiology and synaptic transmission in the brain.
Som Mukhopadhyay, Ph.D., The regulation of manganese (Mn) homeostasis in mammalian cells and in the pathobiology of Mn-induced neurotoxicity. Specifically, evaluating the export of Mn via the Golgi followed by secretion as the primary route of Mn efflux and detoxification in mammalian cells.
Kimberly Nixon, Ph.D., Professor, Pharmacology and Toxicology; focuses on novel mechanisms of and drug discovery for alcoholic neuropathology.
John H. Richburg, Ph.D., Professor of Pharmacology and Toxicology; Mechanisms Regulating Apoptosis/Male Reproductive Toxicology. Peripubertal sensitivity to testicular toxicants.