Publications Cooperativity of PIP2 and PS lipids modulates PH domain bindingFebruary 25, 2025Citation: Chen X, Cardenas AE, Hudson RB, Elber R, Senning EN, and Baiz CR. “Cooperativity of PIP2 and PS lipids modulates PH domain binding.” Biophys J, 124, 7, Pp. 1146-1157. Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionineFebruary 17, 2025Citation: Wulffraat GC, Mamathasateesh S, Hudson R, He B, Jara-Oseguera A, and Senning EN. “Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionine.” bioRxiv. Fluorescence labeling strategies for cell surface expression of TRPV1October 7, 2024Citation: Mott TM, Wulffraat GC, Eddins AJ, Mehl RA, and Senning EN. “Fluorescence labeling strategies for cell surface expression of TRPV1.” J Gen Physiol, 156, 10 Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinasesAugust 20, 2024Citation: Koh DS, Stratiievska A, Jana S, et al. “Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinases.” Elife, 12 Binding-induced lipid domains: Peptide-membrane interactions with PIP2 and PSDecember 23, 2023Citation: Al-Mualem ZA, Chen X, Shafieenezhad A, Senning EN, and Baiz CR. “Binding-induced lipid domains: Peptide-membrane interactions with PIP2 and PS.” Biophys J, 123, 14, Pp. 2001-2011. Structure and function of TRP channelsMarch 1, 2023Citation: Gilbert Q. Martinez and Eric N. Senning. “Structure and function of TRP channels.” In Calcium Signals: From single molecules to physiology, edited by Leslie S. Satin, Manu Ben-Johny, and… read more Mutagenesis studies of TRPV1 subunit interfaces informed by genomic variant analysisJanuary 17, 2023Citation: Taylor M Mott, Jordan S Ibarra, Nivitha Kandula, and Eric N Senning. “Mutagenesis studies of TRPV1 subunit interfaces informed by genomic variant analysis.” Biophysical Journal, 122, 2, Pp. 322-332. Publisher’s… read more Impact of the Protonation State of Phosphatidylinositol 4,5-Bisphosphate (PIP2) on the Binding Kinetics and Thermodynamics to Transient Receptor Potential Vanilloid (TRPV5): A Milestoning StudyAugust 15, 2021Citation: Arman Fathizadeh, Eric Senning, and Ron Elber. “Impact of the Protonation State of Phosphatidylinositol 4,5-Bisphosphate (PIP2) on the Binding Kinetics and Thermodynamics to Transient Receptor Potential Vanilloid (TRPV5): A… read more The Pleckstrin Homology Domain of PLCδ1 Exhibits Complex Dissociation Properties at the Inner Leaflet of Plasma Membrane SheetsMay 28, 2021Citation: Madeline R. Sponholtz and Eric N. Senning. “The Pleckstrin Homology Domain of PLCδ1 Exhibits Complex Dissociation Properties at the Inner Leaflet of Plasma Membrane Sheets.” ACS Chem. Neurosci., 12,… read more Phosphatidylinositol phosphate binding domains exhibit complex dissociation properties at the inner leaflet of plasma membrane sheetsMarch 1, 2021Citation: Madeline Sponholtz and Eric N Senning. “Phosphatidylinositol phosphate binding domains exhibit complex dissociation properties at the inner leaflet of plasma membrane sheets.” bioRxiv. Publisher’s Version With PIPs, you get ZIPs and blips.June 24, 2019Citation: Eric N Senning. “With PIPs, you get ZIPs and blips..” J Gen Physiol, 151, 8, Pp. 971-973. Publisher’s Version Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor.December 18, 2018Citation: Stratiievska A, Nelson S, Senning EN, Lautz JD, Smith SE, and Gordon SE. “Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor..” Elife. Publisher’s Version Measuring distances between TRPV1 and the plasma membrane using a noncanonical amino acid and transition metal ion FRET.January 11, 2016Citation: Zagotta WN, Gordon MT, Senning EN, Munari MA, and Gordon SE. “Measuring distances between TRPV1 and the plasma membrane using a noncanonical amino acid and transition metal ion FRET..”… read more Transition metal ion FRET to measure short-range distances at the intracellular surface of the plasma membrane.January 11, 2016Citation: Gordon SE, Senning EN, Aman TK, and Zagotta WN. “Transition metal ion FRET to measure short-range distances at the intracellular surface of the plasma membrane..” J Gen Physiol, 147,… read more Activity and Ca²⁺ regulate the mobility of TRPV1 channels in the plasma membrane of sensory neurons.January 8, 2015Citation: Senning EN and Gordon SE. “Activity and Ca²⁺ regulate the mobility of TRPV1 channels in the plasma membrane of sensory neurons..” Elife. Publisher’s Version Regulation of TRPV1 ion channel by phosphoinositide (4,5)-bisphosphate: the role of membrane asymmetry.April 1, 2014Citation: Senning EN, Collins MD, Stratiievska A, Ufret-Vincenty CA, and Gordon SE. “Regulation of TRPV1 ion channel by phosphoinositide (4,5)-bisphosphate: the role of membrane asymmetry..” J Biol Chem, 289, 16,… read more Actin polymerization driven mitochondrial transport in mating S. cerevisiae.January 1, 2010Citation: Senning EN and Marcus AH. “Actin polymerization driven mitochondrial transport in mating S. cerevisiae..” PNAS, 107, 2, Pp. 721-725. Publisher’s Version Recent Publications Missense Variant Analysis in TRPV1 ARD Cooperativity of PIP2 and PS lipids modulates PH domain binding Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionine Fluorescence labeling strategies for cell surface expression of TRPV1 Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinases Binding-induced lipid domains: Peptide-membrane interactions with PIP2 and PS
