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Lambowitz Lab
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  • Research Summary
    • (A) Mobile Group II Intron, Evolutionary Ancestors of Retroviruses, Retrotransposons, and Spliceosomal Introns in Eukaryotes.
    • (B) Group II Intron Reverse Transcriptases
    • (C) Reverse Transcriptases Associated with CRISPR-Cas Systems and Other Bacterial and Organellar Reverse Transcriptases
    • (D) Thermostable Group II Intron Reverse Transcriptases (TGIRTs) and Their Applications in High Throughput RNA Sequencing (RNA-Seq).
    • (E) Analysis of Extracellular RNAs, RNA Diagnostics, and Liquid Biopsy and tRNA fragments
  • People
    • Principal Investigator
    • Assistant to Dr. Lambowitz
    • Postdoctoral Associates
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    • Research Associates
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Lambowitz Lab

Department of Molecular Biosciences

100 East 24th St., Stop A5000
Austin, TX 78712 (email)

November 6, 2024, Filed Under: People

Professor Alan Lambowitz

Professor of Molecular Biosciences
Mr. & Mrs. A. Frank Smith Jr. Regents Chair in Molecular Biology
Principal Investigator

Brooklyn College, Department of Chemistry, B.S., 1968, Summa cum laude with honors in Chemistry; Yale University, Department of Molecular Biophysics and Biochemistry, M. Phil., 1970, Ph.D., 1972 (Ph.D. Thesis Advisor Prof. Carolyn Slayman); Postdoctoral Fellow, University of Pennsylvania, Johnson Research Foundation, Department of Biophysics and Physical Biochemistry (Prof. Walter Bonner), 1972-1973; Research Associate, Rockefeller University, Laboratory of Cell Biology (Prof. David Luck), 1973-1975; Senior Staff Fellow, National Institute of Mental Health, Laboratory of General and Comparative Biochemistry, 1975-1976; The Edward A. Doisy Department of Biochemistry, Saint Louis University School of Medicine, Assistant Professor, 1976-1979; Associate Professor, 1979-1982; Professor, 1982-1986; Medical Mycology Center, Washington University School Medicine, Barnes and Wohl Hospitals, (Dr. G. Medoff, Chief), 1978 to 1986; Ohio Eminent Scholar in Molecular Genetics, Professor of Molecular Genetics, Biochemistry, and Medical Biochemistry, The Ohio State University, Colleges of Biological Sciences and Medicine, 1986-1997; Director, Institute for Cellular and Molecular Biology, University of Texas at Austin, 1997-2016; Mr. and Mrs. A. Frank Smith Jr. Regents Chair in Molecular Biology, and Professor of Molecular Biosciences, University of Texas at Austin, 1997-present; Professor, Department of Oncology, Dell Medical School, 2018-present.

Service: NIH Molecular Biology Study Section, 1982-1986; Neurospora Policy Committee, 1982-1986; Ohio Science and Engineering Round Table, 1990-1997; ASM Council, 1991-1993; The Academy of Medicine, Engineering, and Science of Texas, Board of Directors, 2010-2012; Scientific Advisory Board, RNA Institute of the University at Albany-State University of New York, 2012-present; Editor, Plasmid, 1987–1998; Editorial Board, Molecular and Cellular Biology (ASM), 1988-2009; Associate Editor, Fungal Genetics and Biology, 1988-2005; Editorial Board, RNA, 1997-present; Editorial Board, Proceedings of the National Academy of Sciences, 2006-2009; Editorial Board, Mobile DNA, 2014-present.

Honors: Member, National Academy of Sciences (2004); Fellow, American Academy of Arts and Sciences (1995); Fellow, American Association for the Advancement of Science (2001); Fellow, American Academy of Microbiology (2004); Member, Academy of Medicine, Engineering, and Science of Texas (2004); Wilbur Cross Medal, Yale University (2013).

Contact Information

2500 Speedway, Stop A5000
MBB 2.234BA

lambowitz at austin dot utexas dot edu

p: 512-232-3418

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Recent Publications

Structural basis for the evolution of a domesticated group II intron–like reverse transcriptase to function in host cell DNA repair

Tagged With: 2025

Citation: Park SK, Guo M, Stamos JL, Wantae K, Lee S, Zhang YJ, Lambowitz AM. Structural basis of the evolution of a domesticated group II intron-like reverse transcriptase to function in host cell DNA repair. Biochemistry. 2025 July 29; 12231):e2504208122. Download Citation

Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers

Tagged With: 2024

Citation: Yao J, Xu H, Ferrick-Kiddie EA, Nottingham RM, Wu DC, Ares M, Lambowitz AM. Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers. PloS Genet. 2024 Sep 26; 20(9):e1011416 185 (20) :3671-3688. Download Citation

Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2

Tagged With: 2023

Citation: Cui H, Diedrich JK, Wu DC, Lim JJ, Nottingham RM, Moresco JJ, Yates JR, Blencowe BJ, Lambowitz AM, Schimmel P. Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2. Nature Cell Biology [Internet]. 25 :592–603. Download Citation cui_2023.pdf 10.53 MB Full Text News & views highlight:… read more 

Group II-like Reverse Transcriptases Function in Double Strand Break Repair

Tagged With: 2022

Citation: Park SK, Mohr G, Yao J, Russell R, Lambowitz AM. Group II-like Reverse Transcriptases Function in Double Strand Break Repair. Cell [Internet]. 185 (20) :3671-3688. Download Citation park_cell_2022.pdf 12.54 MB Full Text Cell Leading Edge Highlight: Moran, J.V. and Wilson, T.E. Reverse transcriptase meets DNA, again: Possible roles for transposable… read more 

Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling

Tagged With: 2020

Citation: Yao J, Wu DC, Nottingham RM, Lambowitz AM. Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling. eLife [Internet]. Download Citation Last updated on 09/15/2020

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