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Lambowitz Lab
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  • Research Summary
    • (A) Mobile Group II Intron, Evolutionary Ancestors of Retroviruses, Retrotransposons, and Spliceosomal Introns in Eukaryotes.
    • (B) Group II Intron Reverse Transcriptases
    • (C) Reverse Transcriptases Associated with CRISPR-Cas Systems and Other Bacterial and Organellar Reverse Transcriptases
    • (D) Thermostable Group II Intron Reverse Transcriptases (TGIRTs) and Their Applications in High Throughput RNA Sequencing (RNA-Seq).
    • (E) Analysis of Extracellular RNAs, RNA Diagnostics, and Liquid Biopsy and tRNA fragments
  • People
    • Principal Investigator
    • Assistant to Dr. Lambowitz
    • Postdoctoral Associates
    • Research Engineering/Scientist Associates
    • Research Associates
    • Graduate Students
    • Laboratory Assistants
  • Publications
  • Protocols
  • Targetron Design
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Lambowitz Lab

Department of Molecular Biosciences

100 East 24th St., Stop A5000
Austin, TX 78712 (email)

People

July 25, 2025, Filed Under: People

Malisha Welikala

Postdoctoral Associate

Contact Information

2500 Speedway
MBB 2.310AA

malisha dot welikala at utexas dot edu

p: 512-471-4778

January 14, 2025, Filed Under: People

Evangeline Park

Laboratory Assistant

Contact Info

2500 Speedway
MBB 2.210

dm55352 at my dot utexas dot edu

p: 512-471-4778

November 6, 2024, Filed Under: People

Veronica Sirota

Undergraduate Researcher

Contact Information

2500 Speedway
MBB 2.310BA

vksirota at utexas dot edu

p: 512-471-4778

November 6, 2024, Filed Under: People

Diya Mukherjee


Laboratory Assistant

Contact Information

2500 Speedway
MBB 2.210

dm55352 at my dot utexas dot edu

p: 512-471-4778

November 6, 2024, Filed Under: People

Sriya Dommaraju

Undergraduate Researcher

Contact Information

2500 Speedway
MBB 2.310BA

sriyaraju6 at gmail dot com

p: 469-394-6788

November 6, 2024, Filed Under: People

Simon Lee

Graduate Student

Contact Information

2500 Speedway
MBB 2.310A

simon_s_lee at utexas dot edu

p: 408-688-7332

November 6, 2024, Filed Under: People

Seungjin (Daniel) Kim

Graduate Student

Contact Information

2500 Speedway
MBB 2.210A

danielkim0523 at utexas dot edu

p: 512-471-4778

November 6, 2024, Filed Under: People

Dharit Doshi

Graduate Student

Contact Information

2500 Speedway, Stop A5000
MBB 2.234B

ddoshi at utexas dot edu

p: 512-471-4778

November 6, 2024, Filed Under: People

Laura Markham

Research Engineering/Scientist Associate III

Laboratory Manager

Assistant to Dr. Lambowitz

Contact Information

2500 Speedway
MBB 2.210BA

lambowitz.assistant at austin dot utexas dot edu

p: 512-471-4778

November 6, 2024, Filed Under: People

Jun Yao

Research Associate

Contact Information

2500 Speedway
MBB 2.310A

yaojun at austin dot utexas dot edu

p: 512-232-3419

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Recent Publications

Structural basis for the evolution of a domesticated group II intron–like reverse transcriptase to function in host cell DNA repair

Tagged With: 2025

Citation: Park SK, Guo M, Stamos JL, Wantae K, Lee S, Zhang YJ, Lambowitz AM. Structural basis of the evolution of a domesticated group II intron-like reverse transcriptase to function in host cell DNA repair. Biochemistry. 2025 July 29; 12231):e2504208122. Download Citation

Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers

Tagged With: 2024

Citation: Yao J, Xu H, Ferrick-Kiddie EA, Nottingham RM, Wu DC, Ares M, Lambowitz AM. Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers. PloS Genet. 2024 Sep 26; 20(9):e1011416 185 (20) :3671-3688. Download Citation

Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2

Tagged With: 2023

Citation: Cui H, Diedrich JK, Wu DC, Lim JJ, Nottingham RM, Moresco JJ, Yates JR, Blencowe BJ, Lambowitz AM, Schimmel P. Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2. Nature Cell Biology [Internet]. 25 :592–603. Download Citation cui_2023.pdf 10.53 MB Full Text News & views highlight:… read more 

Group II-like Reverse Transcriptases Function in Double Strand Break Repair

Tagged With: 2022

Citation: Park SK, Mohr G, Yao J, Russell R, Lambowitz AM. Group II-like Reverse Transcriptases Function in Double Strand Break Repair. Cell [Internet]. 185 (20) :3671-3688. Download Citation park_cell_2022.pdf 12.54 MB Full Text Cell Leading Edge Highlight: Moran, J.V. and Wilson, T.E. Reverse transcriptase meets DNA, again: Possible roles for transposable… read more 

Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling

Tagged With: 2020

Citation: Yao J, Wu DC, Nottingham RM, Lambowitz AM. Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling. eLife [Internet]. Download Citation Last updated on 09/15/2020

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