Degree: B.S., National Taiwan University, Taiwan
Entered Group: Fall, 2017 (Chemistry program)
Research Projects: Mechanistic Studies of Biosynthetic Pathway of Albucidin
Group Publications:
Ushimaru, R.; Chen, Z.; Zhao, H.; Fan, P.-h.; Liu, H.-w. “Identification of the Enzymes Mediating the Maturation of the Sery-tRNA Synthetase Inhibitor SB-217452 during the Biosynthesis of Albomycins.” Angew. Chem. Int. Ed. 2019, 59, 3558-3562. [PMC7138408].
Zhang, J.; Fan, P.-H.; Lin, G.-M.; Chang, W.-C.; Liu, H.-w. “Recent Progress in the Biosynthesis of Carbohydrate-Containing Natural Products.” In Comprehensive Chemistry of Natural Product Chemistry, Liu, H-w.; Begley, T., Eds.; Elsvier: New York; 2020, 336-392.
Fan, P.-H.; Geng, Y.; Romo, A. J.; Zhong, A.; Zhang, J.; Yeh, Y.-C.; Lee, Y.-H.; Liu, H.-w. “Two Radical SAM Enzymes are Necessary and Sufficient for the In Vitro Production of the Oxetane Nucleoside Antiviral Agent Albucidin.” Angew. Chem. Int. Ed. 2022, 61, e202210362. [PMC9561071]
Lee, Y.-H.; Yeh, Y.-C.; Fan, P.-H.; Zhong, A.; Ruszczycky, M. W.; Liu, H.-w. “Changing Fates of the Substrate Radicals Generated in the Active Sites of the B12-dependent Radical SAM Enzymes OxsB and AlsB.” J. Am. Chem. Soc. 2023, 145, 3656-3664. [PMC9940012]
Fan, P.-H.; Sato, S.; Yeh, Y.-C.; Liu, H.-w. “Biosynthetic Origin of the Octose Core and Its Mechanism of Assembly during Apramycin Biosynthesis.” J. Am. Chem. Soc. 2023, 145, 21361-21369. [PMC10591738]
Sato, S.; Fan, P.-H.; Yeh, Y.-C.; Liu, H.-w. “Complete in vitro Reconstitution of the Apramycin Biosynthetic Pathway Demonstrates the Unusual Incorporation of a β-D-Sugar Nucleotide in the Final Glycosylation Step.” J. Am. Chem. Soc. 2024, 146, 10103-10114. [PMC11317085]