Degree: B.S., National Taiwan University, Taiwan
Entered Group: Fall, 2016 (Chemistry program)
Research Projects: Mechanistic studies of the Biosynthesis of Secondary Metabolites
Group Publications:
Romo, A.; Ikeuchi, H.; Shiraishi, T.; Lin, G.-M.; Geng, Y.; Lee, Y.-H.; Liem, P. H.; Ma, T.; Ogasawara, Y.; Shin-Ya, K.; Nishiyama, M.; Kuzuyama, T.; Liu, H.-w. “Miharamycins and Amipurimycin Biosynthetic Gene Clusters: Unravelling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics.” J. Am. Chem. Soc. 2019, 141, 14152-14159. [PMC6774755].
Zhong, A.; Lee, Y.-H.; Liu, Y.-n.; Liu, H.-w. “Biosynthesis of Oxetanocin A Includes a B12-dependent Radical SAM Enzyme Able to Catalyze both Oxidative Ring Contraction and the Demethylation of SAM.” Biochemistry. 2021, 60, 537-546. [PMC7904626]
Lee, Y.-H.; Liu, H.-w. “Studies of GenK and OxsB, Two B12-Dependent Radical SAM Enzymes Involved in Natural Product Biosynthesis.” Meth. Enzymol. 2022, 667, 71-90. [NIHMSID1788471]
Lee, Y.-H.; Hou, X.; Chen, R.; Feng, J.; Liu, X.; Ruszczycky, M. W.; Guo, J.-M.; Wang, B.; Zhou, J.; Liu, H.-w. “Radical S-Adenosyl Methionine Enzyme BlsE Catalyzes a Radical Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S.” J. Am. Chem. Soc. 2022, 144, 4478-4486.[PMC8934444]
Ren, D.; Lee, Y.-H.; Wang, S.-A.; Liu, H.-w. “Characterization of the Oxazinomycin Biosynthetic Pathway Revealing the Key Role of a Non-heme Iron-dependent Monooxygenase.” J. Am. Chem. Soc. 2022, 144, 10968-10977. [PMC9233086]