Degree: B.S., Tsinghua University
Entered Group: Fall, 2015 (Chemistry program)
Research Projects: Studies of Protein ADP-ribosylation
Group Publications:
Lin, G.-M.; Romo, A. J.; Liem, P. H.; Chen, Z.; Liu, H.-w. “Identification and Interrogation of the Herbicidin Biosynthetic Gene Cluster: First Insight into the Biosynthesis of a Rare Undecose Nucleoside Antibiotic.” J. Am. Chem. Soc. 2017, 139, 16450-16453.
Chen, J.-K.; Lin, W.-L.; Chen. Z.; Liu, H.-w. “PARP-1-Dependent Recruitment of Cold Induced RNA-Binding Protein Promotes Genome Stability.” Proc. Natl. Aca. Sci. USA. 2018, 115, E1759.
Pan, H.-X.; Chen, Z.; Zeng, T.; Jin, W.-B.; Geng, Y.; Lin, G.-M.; Zhao, J.; Li, W.-T.; Xiong, Z.; Huang, S.-X.; Zhai, X.; Liu, H.-w.; Tang, G.-L. “Elucidation of the Herbicidin Tailoring Pathway Offers New Insights into Its Structural Diversity.” Org. Lett. 2019, 21, 1374-1378.
Ushimaru, R.; Chen, Z.; Zhao, H.; Fan, P.-h.; Liu, H.-w. “Identification of the Enzymes Mediating the Maturation of the Sery-tRNA Synthetase Inhibitor SB-217452 during the Biosynthesis of Albomycins.” Angew. Chem. Int. Ed. 2019, 59, 3558-3562. [PMC7138408]
Besandre, R.; Chen, Z.; David, I.; Zhang, J.; Ruszczycky, M. W.; Liu, A.; Liu, H.-w. “HygY is a Twitch Radical SAM Epimerase with Latent Dehydrogenase Activity Revealed upon Mutation of a Single Cysteine Residue.” J. Am. Chem. Soc. 2021, 143, 15152-15158. [PMC8611816]
Zhang, J.; Hou, X.; Chen, Z.; Ko, Y.; Ruszczycky, M. W.; Chen, Y.; Zhou, J,; Liu, H.-w. “Dioxane Bridge Formation in the Biosynthesis of Spectinomycin Involves a Twitch Radical SAM Dehydrogenase that Appears to Have Evolved from an Epimerase.” J. Am. Chem. Soc. 2022, 144, 9910-9919. [PMC9204835]
Chen, Z.; Sato. S.; Geng. Y., Zhang, J.; Liu, H.-w. “Identification of the Early Steps in Herbicidin Biosynthesis Reveals an Atypical C-Glycosylation.” J. Am. Chem. Soc. 2022, 144, in press.