Geng-Min Lin

Geng-Min LinDegree: B.S., National Taiwan University, Taiwan

Entered Group: Fall, 2011

Research Projects: Studies of the Biosynthesis of Secondary Metabolites; Design and Synthesis of Enzyme Inhibitor

Group Publications:

Wang, C.; Chang, W.-C.; Guo, Y.; Huang, H.; Peck, S.; Pandelia, M. E.; Lin, G.-M.; Liu, H.-w.; Krebs, C.; Bollinger, J. M., Jr. “Evidence that the Fosfomycin-producing Expoxidase, HppE, is a Novel Non-heme-iron Peroxidase.” Science 2013, 342, 991-995.

Huang, H.; Chang, W.-C.; Lin, G.-M.; Romo, A.; Pai, P.-J.; Russell, D. H.; Liu, H.-w. “Mechanistic Consequences of Chiral Radical Clock Probes: Analysis of the Mononuclear Non-Heme Iron Enzyme HppE with 2-Hydroxy-3-methylenecyclopropyl Radical Clock Substrates. ” J. Am. Chem. Soc. 2014, 136, 2944-2947.

Lin, G.-M.; Choi, S.-H.; Ruszczycky, M. W.; Liu, H.-w. “Mechanistic Investigation of the Radical S-Adenosyl-methionine Enzyme DesII Using Fluorinated Analogs.” J. Am. Chem. Soc. 2015, 137, 4964-4967.

Lin, G.-M.; Sun, H. G.; Liu, H.-w. “Study of the Uridine 5’-Monophosphate (UDP)-Galactopyranose Mutase Using UDP-5-Fluoro-Galactopyransoe As a Probe: Incubation Results and Mechanistic Implications.” Org. Lett. 2016, 18, 3438-3441.

Jeon, B.-s.; Ruszczycky, M. W.; Russell, W. K.; Lin, G.-M.; Kim, N.; Choi, S.-H.; Wang, S-A.; Liu, Y.-n.; Patrick, J.; Russell, D. H.; Liu, H.-w. “Mechanistic Studies of the SpnF-Catalyzed [4+2]-Cycloaddition in the Biosynthesis of Spinosyn A.” Proc. Natl. Acad. Sci. USA 2017, 114, 10408-10413.

Lin, G.-M.; Romo, A. J.; Liem, P. H.; Chen, Z.; Liu, H.-w. “Identification and Interrogation of the Herbicidin Biosynthetic Gene Cluster: First Insight into the Biosynthesis of a Rare Undecose Nucleoside Antibiotic.” J. Am. Chem. Soc. 2017, 139, 16450-16453.

Ko, Y.; Lin, G.-M.; Ruszczycky, M. W.; Liu, H.-w. “Mechanistic Implications of the Deamination of TDP-4-amino-4-deoxy-fucose Catalyzed by the Radical SAM Enzyme DesII.” Biochemistry 2018, 57, 3130-3133.

Pan, H.-X.; Chen, Z.; Zeng, T.; Jin, W.-B.; Geng, Y.; Lin, G.-M.; Zhao, J.; Li, W.-T.; Xiong, Z.; Huang, S.-X.; Zhai, X.; Liu, H.-w.; Tang, G.-L. “Elucidation of the Herbicidin Tailoring Pathway Offers New Insights into Its Structural Diversity.” Org. Lett. 2019, 21, 1374-1378.

Romo, A.; Ikeuchi, H.; Shiraishi, T.; Lin, G.-M.; Geng, Y.; Lee, Y.-H.; Liem, P. H.; Ma, T.; Ogasawara, Y.; Shin-Ya, K.; Nishiyama, M.; Kuzuyama, T.; Liu, H.-w. “Miharamycins and Amipurimycin Biosynthetic Gene Clusters: Unravelling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics.” J. Am. Chem. Soc. 2019, 141, 14152-14159. [PMC6774755].

Zhang, J.; Fan, P.-H.; Lin, G.-M.; Chang, W.-C.; Liu, H.-w. “Recent Progress in the Biosynthesis of Carbohydrate-Containing Natural Products.” In Comprehensive Chemistry of Natural Product Chemistry, Liu, H-w.; Begley, T., Eds.; Elsvier: New York;. 2020, in press.