Select Publications (Full list on Google Scholar)
Leach, LL, Gonzalez, RG, Jayawardena, SU and Gross, JM (2025). Macrophage/microglia-dependent mechanisms drive retinal pigment epithelium regeneration in zebrafish. Cell Reports 44, 116325. DOI: 10.1016/j.celrep.2025.116325.
Lu, F, Leach, LL and Gross, JM (2023). A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium. Scientific Reports 13(1):3142. DOI: 10.1038/s41598-023-29046-5.
Lu, F, Leach, LL and Gross, JM (2022). mTOR activity is essential for retinal pigment epithelium regeneration in zebrafish. PLoS Genetics 18(3), e1009628. DOI: 10.1371/journal.pgen.1009628.
Leach, LL, Fisher, GB and Gross, JM (2022). Nitroreductase/metronidazole-mediated ablation and a MATLAB platform (RpEGEN) for studying regeneration of the zebrafish retinal pigment epithelium. Journal of Visualized Experiments 181, e63658. DOI: 10.3791/63658.
George, SM, Lu, F, Rao, M, Leach, LL and Gross, JM (2021). The retinal pigment epithelium: development, injury responses and regenerative potential in mammalian and non-mammalian systems. Progress in Retinal and Eye Research 85, 100969. DOI: 10.1016/j.preteyeres.2021.100969.
Leach, LL, Hanovice, NJ, George, SM, Gabriel, AE and Gross, JM (2021). The immune response is a critical regulator of zebrafish retinal pigment epithelium regeneration. Proceedings of the National Academy of Sciences USA 118(21), e2017198118. DOI: 10.1073/pnas.2017198118.
Hanovice, N, Leach, LL, Slater, K, Gabriel, A, Romanovicz, D, Shao, E, Collery, R, Burton, EA, Lathrop, K, Link, BA and Gross, J.M (2019). Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation. PLoS Genetics 15, e1007939. DOI: 10.1371/journal.pgen.1007939.
NCBI GEO Database
Series GSE174538 (bulk RNA-seq data from larval zebrafish RPE – Lu et al., 2022)
Series GSE155294 (bulk RNA-seq data from larval zebrafish RPE – Leach et al., 2021)
Series GSE155295 (bulk RNA-seq data from larval zebrafish ocular macrophages/microglia – Leach et al., 2021)
GitHub RpEGEN (MATLAB)
