CAVS-MS Purpose Determining whether use of Central Vein Sign criteria improves diagnostic specificity for MS in people presenting with atypical symptoms. Determining whether the Central Vein Sign predicts development of clinical MS in individuals with suggestive radiologic findings but no symptoms. Patient Population A total of 400 patients; 200 typical presentations, 200 atypical presentations. Men and women, aged 18-65 years who are seen at MS specialty referral centers for clinical suspicion of MS. Research Method CAVS-MS is a multi-center, observational, cohort study across the United States and Canada. Patients will undergo MRIs to assess the development or appearance of new lesions over two years. Patients will complete forms assessing their mental and physical health at multiple increments throughout the two years. Clinical Trial Information https://clinicaltrials.gov/study/NCT04495556?term=CAVS-MS&rank=1 Status: Active, Not Recruiting The CAVS-MS Study at the University of Texas at AustinLocations: UT Health Austin, MS and Neuroimmunology CenterDell Medical School & Dell Seton Medical CenterLocal site principal investigator: Leorah Freeman, MD, PhDResearch coordinators: Alejandra Gomez-Lopez, BA; Gabriella Cozzani, BSA Sponsor The Cleveland Clinic The image banner on this site is AI generated
