Register: The Oskar Fisher Lecture Series: Neural Basis of a Silent Alzheimer’s Disease Phase

The Oskar Fischer Lecture Series features invited scholars working at the vanguard of new ideas on the mechanisms, diagnosis and treatment of dementing illnesses.

The eighth lecture of the series will feature neuroscientist Inna Slutsky, Ph.D. Dr. Slutsky is the chair of the Department of Physiology and Pharmacology at the Sackler Faculty of Medicine, Tel Aviv University, Israel. Her research focuses on understanding the basic mechanisms that maintain stability-plasticity balance in hippocampal circuits and initiate circuit-wide dysfunctions during the presymptomatic phase of Alzheimer’s disease.

Using advanced optical imaging, electrophysiology and molecular biology tools, Dr. Slutsky’s team uncovered the mechanisms that drive synaptic, network and cognitive impairments in Alzheimer’s disease models. Currently, her team explores the principles and mechanisms underlying stability of neural circuits’ functioning and the role of mitochondria in this regulation. Recently, she proposed a new hypothesis stating that dysregulation of homeostatic firing rate set points during low-arousal brain states drives Alzheimer’s pathophysiology. Her recent discoveries form the basis of FutuRx’s company Selene Therapeutics, pioneering a new conceptual strategy to treat epilepsy and Alzheimer’s disease by lowering activity set points in brain circuits.

Professor Slutsky completed her Ph.D. at the Hebrew University of Jerusalem and postdoctoral study at the Picower Institute for Learning and Memory at the Massachusetts Institute of Technology.

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This event has in-person and remote options for you to select from. Registration is required to receive the stream link