Multidisciplinary Providers Contribute to Scholarly Literature

Our program contributes scholarly articles on a variety of topics, and we encourage publications from all members of the team. The featured articles below, for example, include contributions from child neurologists, child neurology residents, a nurse practitioner, and a pediatric neurosurgeon.

Kevin Kumar, MD, PhD, assistant professor of neurosurgery at Dell Medical School, was the lead author of a recent Frontiers in Surgery article that analyzed the effectiveness of deep brain stimulation (DBS) and responsive neurostimulation (RNS) in children with drug-resistant epilepsy. DBS was used primarily for palliation of generalized or mixed drug-resistant epilepsy after other therapies failed, and 71% of these patients experienced a 50% or greater seizure reduction. RNS was used for patients with a better-defined seizure focus and no prior epilepsy surgery. Eighty percent of the RNS patients achieved clinical seizure freedom, and 20% had a 90% reduction in seizure burden. RNS also provided valuable data for future interventions. Both DBS and RNS are useful options for children with drug-resistant epilepsy.

Child neurology residents Catherine Kronfol, MD, PGY-4, and Aaron Hocher, MD, PGY-3, described a newborn who was transferred from another hospital because of metabolic acidosis, respiratory distress, and suspected seizures. Abnormal facial movements and posturing were initially suspected to represent seizures, but continuous electroencephalography showed no epileptiform discharges during the movements. His initial serum ammonia level was dramatically elevated (1284 μg/dL). Urine organic acids, plasma amino acids, serum pyruvate, and carnitine were normal, but next-generation DNA sequencing of serum confirmed evidence of Ureaplasma urealyticum, an organism that produces copious amounts of ammonia. After treatment with azithromycin, his ammonia level normalized, and when seen at 13 months of age he was developmentally normal. Severe hyperammonemia does not always result from genetic metabolic disorders.

Samantha Irwin, MSc, MB BCh BAO, an associate professor of neurology, and Sara Pavitt, MD, an assistant professor of neurology, reviewed the assessment and management of headache in children in the American Academy of Pediatrics’ education journal Pediatrics in Review. The far-reaching review includes typical clinical manifestations, common headache triggers, red flags that could indicate more serious conditions, the epidemiology of headaches in children, symptomatic and preventive medications, and neuromodulation devices for headache.

Janet Wilson, MSN, CPNP-PC, has years of experience treating children with drug-resistant epilepsy with the ketogenic diet. She frequently volunteers in Kenya and the Caribbean islands, where the use of the ketogenic diet is often hindered by the cost of nutritional supplements and extensive laboratory monitoring and by the limited availability of the ingredients commonly used to make diet recipes. She has identified locally available ingredients that are suitable for maintaining ketosis and taught people how to implement the diet. In a recent issue of Epilepsy Currents, Wilson teamed with colleagues from the United States, Jamaica, India, and Kenya to discuss optimization of refractory epilepsy care in resource-limited settings, including implementation of dietary therapies.

Uchitel J, Lui A, Knowles J, Parker JJ, Phillips HW, Halpern CH, Grant GA, Buch VP, Hyslop A, Kumar KK. Intracranial neuromodulation for pediatric drug-resistant epilepsy: early institutional experience. Front Surg. 2025 Apr 8; 12:1569360. https://doi.org/10.3389/fsurg.2025.1569360

Pavitt S, Irwin SL. Headache care. Pediatr Rev. 46(3):129-138. https://doi.org/10.1542/pir.2024-006402

Kronfol C, Hocher A, Roach ES. Neonatal hyperammonemia due to Ureaplasma sepsis. Ann Child Neurol Soc. 2025;3:57-58. https://doi.org/10.1002/cns3.20107

Yardi R, Radhakrishnan K, Samia P, Wilson J, Ali A. Managing refractory epilepsy in a resource-limited setting—doing more with less. Epilepsy Curr. Published 2025 May 27. https://doi.org/10.1177/15357597251318562