Biobank Collection Advances Pediatric Neurological Research

Despite decades of research, our understanding of the pathophysiology of many central and peripheral nervous diseases and disorders remains limited. Analysis of histology, biomarkers, and genetic markers is needed to enhance our understanding of the mechanisms of neurological-related diseases. Furthermore, cell lines derived from these diseased tissues are needed to create animal models and other in vitro testing.

The Neurosurgery Biobank at Dell Medical School is a repository of biological specimens collected from adult and pediatric patients undergoing neurosurgical procedures at Dell Children’s Medical Center, Dell Seton Medical Center at The University of Texas, and Ascension Seton Medical Center Austin. The biobank allows researchers to better understand the biochemical, genetic, and biomechanical mechanisms behind neurological diseases and paves the way for innovative genetic treatments and breakthroughs. This is particularly important for children, who are often underrepresented in research and therapeutic innovation for many of these conditions.

Led by Vincent Wang, MD, PhD, of the Department of Neurosurgery with contributions by pediatric neurosurgeon Kevin Kumar, MD, PhD, the biobank has received thousands of samples from more than 200 patients, primarily consisting of various central nervous system tumor specimens. The specimens, including tissues used to generate tumor cell lines, are processed and stored in the Department of Neurosurgery. “The biobank highlights our commitment to advancing research and improving patient care,” said Pierrick Millet, MD, biobank senior research program coordinator who works in the Kumar lab at UT Austin. “Its growth will allow us to contribute to the scientific community and further solidify Dell Medical School as a leader in this field.”