Project Summary

The ADvance II Study is researching the use of a surgically implanted device that delivers mild electrical pulses to specific areas of the brain in people with Alzheimer’s.
This deep brain stimulation (known as DBS) will be given to the fornix, a place in the brain that plays a central role in memory. Based on results of a study of 42 patients with Alzheimer’s*, the ADvance II study is designed to evaluate the is safety and efficacy of DBS of the fornix (DBS-f) for patients with mild Alzheimer’s disease.

The primary efficacy objective of this study is to test the hypothesis that DBS-f stimulation (ON) will slow cognitive and functional progression of AD, as compared to no stimulation (OFF), by measuring baseline (pre-implantation) to 12-month change in the integrated Alzheimer’s disease rating scale (iADRS).

Click here to learn more about ADvance II and its ongoing clinical study

The ADvance II study is sponsored by Functional Neuromodulation Ltd