We generated a strain of the intracellular bacteria, Shigella that preferentially infects Glioblastoma brain tumor cells (https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1229747/full).
These microscopy images are of glioblastoma (GBM) cells incubated with GBM-infecting shigella. F-actin indicates the cell boundary to demonstrate that the bacteria (rendered green) are inside the cell. We envision these bacteria as a drug delivery platform to eradicate any GBM tumor missed during surgery.
