Lead Story

Single-particle tracking (SPT) has enabled direct observations of particle dynamics with sub-millisecond temporal resolution and submicron spatial resolution inside complex biological systems. Molecular trafficking within cells, tissues, and engineered 3D multicellular models is critical to the understanding of the development and treatment of various diseases including cancer. To achieve deep… read more 

Among those water-soluble noble metal nanoclusters newly developed, DNA-templated silver nanoclusters (DNA/AgNCs) have attracted great interest in biosensing owing to a number of useful photophysical and photochemical properties. Controlled conversion of DNA/AgNCs between bright and dark states by guanine proximity has led to the invention of a new molecular probe,… read more 

Single-molecule detection provides researchers with a unique method to probe kinetics of biomolecules in their native environment, without the need to synchronize the molecular states. In contrast to other confocal-feedback 3D single-particle tracking demonstrations, we tracked single DNA reporter strands inside a live cell and measured their annealing-melting kinetics. Our… read more