Examining neural circuit mechanisms that lead to psychiatric disease
The Donegan Lab investigates how stress throughout the lifespan affects neural circuit function and leads to behaviors associated with psychiatric disease. Previously, we have identified specific pathways from the ventral hippocampus associated with discrete symptoms of schizophrenia. Using cutting edge techniques, such as eGRASP and fiber photometry, we have characterized the anatomy and function of these circuits in the healthy brain. Currently, our lab is examining the effect of chronic adult stress on these ventral hippocampal circuits.
The ultimate goal of the Donegan Laboratory is to understand how neural circuit function is altered in psychiatric disease in order to find new and more effective therapeutic strategies.
Donegan Lab is affiliated with the Department of Psychiatry and Behavioral Sciences at Dell Medical School.