Immunotherapy and targeted hyperthermia Immune checkpoint therapy has become the first widely adopted and successful immunotherapy for the treatment of late stage melanoma and holds great promise for achieving success in a broad range of cancers. Up to ~40% of patients experience complete responses, showing long term remission. The key… read more
Lead Story
Noninvasive skin cancer diagnosis
Mortality throughout the world due to cutaneous melanoma has been increasing over the past two decades, accounting for 3% of deaths caused by cancer. Because survival rates increase substantially when diagnosed at an early stage, successful treatment of melanoma depends on early detection. We have been working to develop optical… read more
Image-guided surgery using Raman microscopy
Surgery remains a primary tool to remove cancerous tumors; however, a major challenge of the procedure is incomplete surgical removal leading to recurrence, costly adjuvants and secondary surgeries. The current method to determine surgical success relies on histopathology, after the surgery is complete. We are developing methods to assess surgical… read more
Imaging fiber alignment
We have developed a technique called polarized spatial frequency domain imaging (pSFDI) to noninvasively image fiber orientation and alignment in tissues with highly aligned structure such as heart valve leaflets. This reflectance-based technique does not require tissue processing (e.g. fixation or clearing) and can be performed dynamically while tissues are… read more
