August 5, 2019, Filed Under: 2019, reflections, researchSummer Research Poster Symposium Not going to lie, the poster and abstract week might have been the most stressful part of this summer. In my opinion, this past week was the culmination of our research this summer because it was the week where we had to take our experiences and condense it to just the informative, practical, and educational aspects. It was particularly difficult for me because I have never written something like an abstract or made a scientific poster, so I was still learning as I went. What made it a little more difficult is that my specific research this summer has largely been working on my mentor’s project which won’t be finished while I’m here, so at first I didn’t really know what to write about. So the closer we got to the deadline the more stressed I got, but eventually, my mentor was a big help and worked me through some of my initial ideas and gave me some advice and edits, and eventually my poster and abstract were ready to go. Leading up to the poster session, I had been really worried about presenting my research because I felt I didn’t know enough about my project. I asked my mentor and other people in my lab questions about some of the most basic things of our lab just to make sure I had it right or knew what I was saying. I spent the nights before the session just practicing my speaking and going over the information on the poster, and still, I felt unsure about my abilities, which I think is natural. After talking to the other interns, I almost feel that I went overboard on the preparation for the presentation, but I did it anyway because above all I wanted to feel confident in what I was saying and know that it was true. The poster session turned out to be not nearly as bad as I thought it would be (Check at the end for lots of photos). My biggest takeaways from the poster session were that I knew more than I thought I did and that speaking about my project was scary the first two times, but after that, it wasn’t stressful at all. I remember being really afraid when the first person came to my poster and I explained to them my research, but by the third or fourth person I realized that I didn’t have to worry, I just had to say what I know. One of the graduate students in my lab complimented my confidence in my presentation, saying that using confidence when speaking is one of the most important parts about a scientific presentation. But something that I will never forget is the feeling of being surrounded by all these posters with amazing work on them. Something I wish I got the chance to do was to walk around more because I didn’t get to see nearly as many posters as I had liked. Everyone in that room had been doing amazing work this summer, from ethnic demographic research of the city of Austin to cancer research to research about fire ants, there were just so many great ideas and posters that represented months of hard work. Everyone in that room is an incredibly driven and intelligent person, and it’s realizations like that that make me excited to be apart of a community like this. This was my first poster presentation, and I’m really glad it happened. I feel like every time afterward won’t nearly be as scary, I just had to rip the band-aid off this first time. Poster presentations and scientific meetings or conventions, in general, are important because I feel like they are the gathering place of scientific thought, the birthplace of scientific inspiration and innovation. Where intellectuals from many different backgrounds doing their own amazing work all come together to admire and celebrate the work of the scientific community as a whole. Now, I’m not saying that this small poster presentation by University of Texas undergraduates achieved all of this, but that it was a smaller representation of the larger scientific community, and it’s how I imagine the BMES conference will be like in Philadelphia. Can’t wait 🙂 -Michael Miramontes, University of Notre Dame Here are the photos I promised! Jaime Chen, U of Illinois at Urbana-ChampaignJessica Heard, Auburn UniversityMichael Miramotnes, U of Notre DameJoshua Ni, Johns Hopkins UniversitySimon Blanchard, Villanova UniversityMaggie Cook, Arizona State UniversityJoel Mudloff, UT at El PasoReetwan Bandyopadhyay, U of PittsburghJubin George, U of ArizonaMia Harguchi, Yale UniversityDara Oluwadara, Rice UniversityAngelica Marquez, UT at El Paso
July 4, 2019, Filed Under: 2019, cancer, reflectionsReflection on Reading Emperor of All Maladies The Emperor of All Maladies is a biography of the unraveling mystery of cancer in the search for a cure. In the opening of the book, I found alarming statistics the author gives us. Only in the United States, “one in three women and one in two men will develop cancer during their lifetime”. Siddhartha Mukherjee, has interesting storytelling that immerses you in the mind of cancer patients, physicians and researchers, giving historical context as we move along the different approach and discoveries in the war against cancer. When reading the book, the definition and history of cancer is built. At the beginning, Dr. Sidney Farber, a pediatric pathologist, decided from the basement of the Children’s Hospital to look at cancer from a new perspective, starting from the building blocks of the cells. An approach that seems basic in today’s research, but revolutionary at this point in history. The building of our understanding came from developing and trying many treatments over the years. The Emperor of the Maladies explains the history of breast cancer treatments starting from the mastectomy to radiation, chemotherapy, hormonal therapy, and target therapy. The Emperor of All Maladies by Siddhartha Mukherjee, background is my working space in Dr. Pengyu Ren’s Computational Biomolecular Engineering Lab Today, we are still fighting the same war. When Mukherjee describes the search of the most favorable cocktail of chemicals for an anticancer drug, he states that, “the fundamental biology of cancer was so poorly understood that defining such molecular targets was virtually inconceivable in the 1960s.” Working in a molecular dynamics laboratory has given me the opportunity to learn about the new technologies resources that we have today. To understand how a molecule can affect a cell, an organ, and ultimately a person’s life. I feel encouraged in my everyday work of programming and mathematical formulas to see further and feel a sense of responsibility of being part of this fight in history to cure cancer. -Angelica Marquez, University of Texas at El Paso
June 24, 2019, Filed Under: 2019, cancer, reflections, researchResearch Ethics Reflection As we enter the fourth week of our summer program, many of us are starting to venture into our research projects in a markedly more independent manner than before. The training wheels are finally starting to come off! This transition marks an important point in our journey as budding cancer researchers, as it comes not only with the excitement of greater freedom, but the critical responsibility of upholding scientific integrity. This is a picture of three tumor spheroids under the microscope, composed of cells from the 4T1 breast cancer line, that I took last week. These spheroids are used to model the tumor microenvironment in-vivo. During the past week’s seminar, we as a group discussed different types of ethical violations in science. We also went over case studies that stood out for their blatant disregard of proper scientific conduct. The worst part was that the papers associated with these fraudulent studies were cited by thousands upon thousands of other researchers around the world. The resulting networks of knowledge all inevitably came crashing down when their feeble foundation was exposed, effectively resulting in the waste of all the time, effort, and money that went into their construction. Scientific progress is achieved through purposeful research, and research only has purpose if it is conducted ethically. This is what we have been taught so far in our time at UT Austin, and it is what we must remember as we continue to work on our projects. Cancer is a deadly disease that can only be overcome through the proper and consistent effort of researchers in the lab. To this end, we can best contribute to the fight by creating our models, collecting our data, and presenting our results with the utmost integrity. My friends and I at the BME CUReS Cancer REU have the next 7 weeks to make as much progress towards winning the War on Cancer as possible. By prioritizing ethical conduct, making it the hallmark of our work, I know that we will do great things! – Reetwan Bandyopadhyay, University of Pittsburgh