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reflections

August 4, 2016, Filed Under: 2016, reflections, research

Ethics in Research

Growing up as a kid, science class was taught based on the facts that we have gained throughout historical records. Did Sir Isaac Newton record study after study and write the about his laws of motion to describe the effects of gravity and momentum? Yes, that is a fact. Did Galileo Galilei become the first person to openly challenge the Catholic Church and state that the sun is truly the center of our solar system not the Earth? Yes, that is a fact. These were revolutionary ideas in their respective eras and the only way that people were able to determine these ideas as fact was through numerous replications of their experiments by different people all across the globe.

Galileo Galilei (1564-1642). Source: famousscientists.org
Galileo Galilei (1564-1642). Source: famousscientists.org

Every scientist wants their research to go down in the history books and to set the standards for their respective fields like what Newton and Galileo did for their fields. This burning passion though skews some lines about the number of times experiments should be replicated before being published. Some people pump out data too quickly so not all of the possible issues have been troubleshot yet, so other scientists might doubt the validity of the results. This means that science actually takes a really, really long time before anything can even be presented to the scientific community.

Some researchers are willing to even go to extraordinary measures like faking their lab results just so they can be published have five minutes of fame and glory. The only problem is that in science they have systems to catch these frauds. People have designated jobs to repeat people’s scientific experiments in order to prove their validity. It’s fairly easy to catch them too because after a few people talk and agree that the results are not replicable the publication is tainted. This is the worst thing that can happen to scientist; once your reputation is tainted it’s nearly impossible to ever recover. Not only is your reputation important, but also whoever your scientific mentor is really impacts how much faith people put into your findings.

Isaac Newton's academic family tree. Source: irishtimes.ocm
Isaac Newton’s academic family tree. Source: irishtimes.ocm

The REU program had a really extensive discussion one of the first weeks over the importance of producing truthful, replicable results. The biggest example that was hammered home was the effects of one graduate student at a Japanese university that produced some truly revolutionary research. Nobody could reproduce this data. People investigated further and further and found that the images that this researcher had published were actually the combination of two totally different samples that were doctored together. There was outrage in the scientific community. The woman had her PhD revoked by her university and her entire lab’s careers were tarnished and they were scoffed at for being associated with the fraud. The woman and her co-author were both so ashamed by the backlash that they both committed suicide shorty after.

Not only does the number of times that tests have to be run hinder the scientific process, but the number of safety regulations that have been implemented recently has really slowed things down. Before, scientists would test on animals and even humans freely without too many restrictions, now for any similar testing any proposed experiments have to be reviewed by an entire board at the university. The whole process has turned science into a much safer endeavor for the patients involved as well as the environment. However, the drawbacks are slowing down the timeline for potential products and drugs that could protect the world and save thousands of lives. Think about how far you would go; how many rules would you bend to make your mark on science and save the world?

Source: Illinois Institute of Technology
Source: Illinois Institute of Technology

-Grant Ashby, Georgia Tech

July 27, 2016, Filed Under: 2016, cancer, reflections, research

Finding a Cure for Cancer Together

I cannot believe it is week 8. I have grown tremendously from nearly starting at the beginning of cell culturing.  I knew that researchers worked as a team, though they still had their individual projects. There are constant communication and collaboration efforts even in their individualized projects. The research community is constantly interacting with one another.

Photo source: Carabiner Communications
Photo source: Carabiner Communications

The question is, do different areas of science and engineering communicate together?

Cancer is a fight that is different for each person it affects, but the fight against cancer is a united front of various routes. The research paths lead to the same end in the fight against cancer, but the team effort is what keeps the fight alive and growing. Cancer is a fight that is different for each person, and individualized treatments are needed for each battle. There is more than one way to fight cancer. The cure itself is not just one method but several combined methods that take out cancer on all the possible fronts.

During this summer, I have been around different types of engineering from biomedical to mechanical to material science and biology. I have learned that collaboration is endless because everyone has different ideas and knowledge, and different viewpoints are necessary. I have learned so much not only about cancer and how the cancer cells interact with their microenvironment, but also how biomaterials can be used to mimic the cancer microenvironment.

– Alston-Lauren Feggins, Florida Institute of Technology

July 8, 2016, Filed Under: 2016, cancer, reflections, research, texas4000

Engaging the Fight Against Cancer with Texas 4000

“Cancer begins and ends with people.
In the midst of scientific abstraction, it is sometimes possible to forget this one basic fact.”
–June Goodfield.

Before this summer, I viewed the fight against cancer solely as a scientific race to find a cure. As I began my participation in the BME CUReS REU program, my perspective of the fight against cancer has been changed and expanded. Through my research in the lab and reading of Emperor of All Maladies: A Biography of Cancer, I have come to realize that the complexity of the nature of cancer as a disease and its variance among its victims prevents there ever being one single drug that provides a universal cure. Yet, in order to achieve the ultimate goal of eliminating the disease of cancer, it is going to take several different effective treatments. In consequence, winning the war against cancer requires an entire army – a community. A community of researchers to share findings to better the understanding of cancer as a disease and to find more effective treatments. A community of doctors to communicate the needs of patients and the successes and failures of treatments. A community of people to raise the public’s awareness and funds for the fight against cancer.

In a community, there are several different groups of individuals who hold various roles, all of which are vital to the functionality of the community. Just as in any functioning body, one part of a community cannot thrive without the other. In the cancer community, doctors and researchers could not collaborate and create effective treatments without funding. It is the individuals of the cancer community that dedicate their time to share their personal encounters with cancer, to host fundraising events, to campaign for government funding, to raise public awareness who come up with the funding. Thus, these are the individuals who fuel the fight against cancer.

A great example of such individuals are those who make the Texas4000 happen. These individuals dedicate two years of their life to raise $4,500 total funds for cancer research and to train physically, emotionally, and mentally to ride a bike 4000 miles. The strenuous 4000 mile bike ride from Austin to Anchorage mirrors the exhausting fight cancer patients face every day. While some may ride in memory of someone who encountered cancer as others ride because they personally are a survivors, all ride for the sole purpose of raising hope and public knowledge in the fight against cancer.

Without the funds raised by the Texas4000 riders, research programs like BME CUReS would not be happening. Every day in the labs, I use numerous pipet tips, reagents, cell lines, and fancy other equipment – all to better understand cancer. Yet, all these tools wear high price tags. Due to dedication of the Texas4000 individuals, this summer, I can contribute research that will bring the cancer community one step closer to fighting off cancer.

-Rachel Hegab, Louisiana Tech University

On Friday, July 1, four Texas 4000 riders from the 2017 visited the REU weekly seminar to talk about why they ride: Marc, Margo, Luis, and Valerie. We also made cards for the 2016 Sierra team and will be sending them to the Portland Day 45 mail drop!

BME CUReS Cancer Summer Scholars and 2017 Texas 4000 Riders on July 1, 2016
BME CUReS Cancer Summer Scholars and 2017 Texas 4000 Riders on July 1, 2016
Cards for 2016 Sierra Team!
Cards for 2016 Sierra Team!
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