A complete bibliography can be accessed at MyNCBI

Select publicatons:

Zhao X, Perez. JM, Faull PA, Chan C, Munting FW, Canadeo LA, Cenik C, and Huibregtse JM. 2024. Cellular Targets and lysine selectivity of the HERC5 ISG15 Ligase. iScience. PMCID: PMC10831901

Swaim CD, Perng YC, Zhao X, Canadeo LA, Harastani HH, Darling TL, Boon ACM, Lenschow DJ, and Huibregtse JM. 2021.  6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro. iScience.  PMC8487320

Swaim, C. D., Canadeo, L. A., Monte, K. J., Khanna, S., Lenschow, D. J., and Huibregtse, J. M. 2020. Modulation of extracellular ISG15 signaling by pathogens and viral effector proteins. Cell Reports 31:107772. PMC7297157

Ryu, W. W., Stewart, R., Pectol, C., Ender, N., Wimalarathne, O., Lee, J.-H., Zanini, C.P., Harvey, A., Huibregtse, J. M., Mueller, P., And Paull, T. T. 2020. Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.  PLoS Biology 18:e3000606. PMC7392334

Tomita, T., Huibregtse, J. M., and Matouschek, A. 2020. A masked initiation region in retinoblastoma protein regulates its proteasomal degradation. Nature Commun. 11:2019. PMC7181824

Swaim, C. D., Canadeo, L. A., and Huibregtse, J. M.  Approaches for investigating the extracellular signaling function of ISG15.  Methods in Enzymology 618:211-227. PMC6472260

O’Connor, H. F., Swaim, C. D., Canadeo, L. A., and Huibregtse, J. M.  2018.  Ubiquitin-Activated Interaction Traps (UBAITs):  Tools for capturing protein-protein interactions.  In The Ubiquitin Proteasome System:  Methods and Protocols.  Methods in Mol. Biol., Springer, 1844:85-100.  DOI: 10.1007/978-1-4939-8706-1_7

Swaim, C. D., Scott, A. F., Canadeo, L. A., and Huibregtse, J. M.  2017.  Extracellular ISG15 signals cytokine secretion through the LFA-1 integrin receptor.  Mol. Cell 68:581-590.  PMC5690536

O’Connor, H. F., and Huibregtse, J. M.  2017.  Enzyme-substrate relationships in the ubiquitin system: approaches for identifying substrates of ubiquitin ligases.  Cell Mol Life Sci. 74:3363-3375. PMC5545068

Huibregtse, J. M., and Matouschek, A.  2016.  Ramping up degradation for proliferation.  Nature Cell Biol. 18:141-142. DOI: 10.1038/ncb3306

Canadeo, L. A., and Huibregtse, J. M.  2016.  A billion ubiquitin variants to probe and modulate the UPS.  Mol. Cell 62:2-4.  DOI: 10.1016/j.molcel.2016.03.023

O’Connor, H., Lyon, N., Leung, J. W., Agarwal, P., Swaim, C., Miller, K. M., and Huibregtse, J. M.  2015.  Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners.  EMBO Reports 16:1699-1712.  PMC4693525

Wang, F., Canadeo, L., and Huibregtse, J. M.  2015.  Ubiquitination of newly synthesized proteins at the ribosome.  Biochemie 114:127-133. PMC4458410

Huibregtse, J. M, and Rohde, J. R.  2014.  Hell’s BELs:  Bacterial E3 Ligases that exploit the eukaryotic ubiquitin machinery.  PLoS Pathogens 10(8):e1004255. PMC4133400

Wang, F., Durfee, L. A., and Huibregtse, J. M.  2013. Cotranslational ubiquitination mediates the degradation of newly synthesized proteins.  Mol. Cell 50:368-378. PMC3654026

Bogunovic, D., Byun, M., Abhyankar, A., Durfee, L. A., Sanal, O., Mansouri, D., Grant, A. V., Adimi, P., Mansouri, N., Okada, S., Bryant, V., Kong, S.-F., Kreins, A., Boisson, B., Zadeh, S. K., Darazam, I. A., Schoggins, J. W., Rice, C. C., Al-Muhsen, S., Bustamante, J., Huibregtse, J. M., Abel, L., Boisson-Dupuis, S., and Casanova, J.-L.  2012.  Impaired IFN-g immunity and mycobacterial disease in humans with inherited ISG15 deficiency.  Science 337:1684-88. PMC3507439

Kim, H. C., Steffen, A., Chen, J., and Huibregtse, J. M.  2011.  Structure and Function of a ubiquitin binding site within the catalytic domain of a HECT ubiquitin ligase. EMBO Reports, 12:334-341.  PMC3077248

Durfee, L. A., Lyon, N., Seo, K., and Huibregtse, J. M.  2010.  The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the anti-viral function of ISG15.  Mol. Cell 38:722-732. PMC2887317

Kim, HC and Huibregtse, J. M. 2009.  Polyubiquitination by HECT E3s and the Determinants of Chain Type Specificity.  Mol. Cell. Biol.  29:3307-3318. PMC2698738

Durfee, L. A., Kelley, M. L., and Huibregtse, J. M.  2008.  The basis for selective E1-E2 interactions in the ISG15 system.   J. Biol. Chem. 283:23895-902. PMC2527107