Jara-Oseguera Lab

PUBLICATIONS

PubMed

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Deep mutational scan of the pore of the cold-sensing TRPM8 channel

HaloTag-based approach to quantify subcellular localization of TRPV3 channel

Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionine

Structural dynamics at cytosolic interprotomer interfaces control gating of a mammlian TRPM5 channel

Ruthenium red: Blocker or antagonist of TRPV channels?

Implications of a temperature-dependent heat capacity for temperature-gated ion channels

Cannabidiol sensitizes TRPV2 channels to activation by 2-APB

PUBLICATIONS AS TRAINEE

Global alignment and assessment of TRP channel transmemberane domain structures to explore functional mechanisms

The ion selectively filter is not an activaton gate in TRPV1-3 channels

Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity

TRPM channels come into focus

Heat activation is intrinsic to the pore domain of TRPV1

Engineering vanilloid-sensitivity into the rat TRPV2 channel

An external sodium ion binding site controls allosteric gating in the TRPV1 channels

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

The role of allosteric coupling on thermal activation of thermo-TRP channels

Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

TRP Channel Gating Physiology

Identification of a Binding Motif in the S5 Helix that Confers Cholesterol Sensitivity to the TRPV1 Ion Channel

Uncoupling charge movement from channel opening in voltage-gating potassium channels by ruthenium complexes

Molecular Mechanisms of TRPV1 Channel Activation

The helical character of the S6 segment of TPRV1 channels

Structural determinants of gating in the TRPV1 channel

Properties of the inner pore region of TRPV1 channels revealed by block with quanternary ammoniums

The TPRV1 channel as a target for the treatment of pain

TRPV1: On the Road to Pain Relief

A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic

On the Mechanism of TBA Block of the TRPV1 Channel