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Lambowitz Lab
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  • Research Summary
    • (A) Mobile Group II Intron, Evolutionary Ancestors of Retroviruses, Retrotransposons, and Spliceosomal Introns in Eukaryotes.
    • (B) Group II Intron Reverse Transcriptases
    • (C) Reverse Transcriptases Associated with CRISPR-Cas Systems and Other Bacterial and Organellar Reverse Transcriptases
    • (D) Thermostable Group II Intron Reverse Transcriptases (TGIRTs) and Their Applications in High Throughput RNA Sequencing (RNA-Seq).
    • (E) Analysis of Extracellular RNAs, RNA Diagnostics, and Liquid Biopsy and tRNA fragments
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Lambowitz Lab

Department of Molecular Biosciences

100 East 24th St., Stop A5000
Austin, TX 78712 (email)

December 13, 2024, Filed Under: Publications

Generalized bacterial genome editing using mobile group II introns and Cre-lox.

Citation:

Enyeart PJ, Chirieleison SM, Dao MN, Perutka J, Quandt EM, Yao J, Whitt JT, Keatinge-Clay AT, Lambowitz AM, Ellington AD. Generalized bacterial genome editing using mobile group II introns and Cre-lox. Mol Syst Biol [Internet]. 9 :685.

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Last updated on 02/12/2015

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Recent Publications

Real-Time Visualization of G2L4 Reverse Transcriptase in DNA Repair via Microhomology- Mediated End Joining

Citation: Zhang P, Guo M, Zhang YJ, Lambowitz AM, Lin YC. Real-Time Visualization of G2L4 Reverse Transcriptase in DNA Repair via Microhomology-Mediated End Joining. bioRxiv [Preprint]. 2026 Mar 17:2026.03.13.711756. doi: 10.64898/2026.03.13.711756. PMID: 41890004; PMCID: PMC13015716.

RNASET2 degrades mRNAs that protect against lipotoxicity

Citation: Shuiling Zhao, Stevens Bontemps, Ryan M. Nottingham, Jun Yao, Mariana Acuña, David E. Cohen, Alan M. Lambowitz, Jean E. Schaffer, Molecular Metabolism, Vol 110, 2026, 102409, ISSN 2212-8778, https://doi.org/10.1016/j.molmet.2026.102409.

Pervasive enhanced transcription in inflammatory breast cancer tumors and PBMCs impacts RNA splicing and intronic RNAs in plasma

Citation: Dennis Wylie et al. ,Pervasive enhanced transcription in inflammatory breast cancer tumors and PBMCs impacts RNA splicing and intronic RNAs in plasma.Sci. Adv.12, eadu0031(2026).DOI:10.1126/sciadv.adu0031

Structural basis for the evolution of a domesticated group II intron–like reverse transcriptase to function in host cell DNA repair

Tagged With: 2025

Citation: Park SK, Guo M, Stamos JL, Wantae K, Lee S, Zhang YJ, Lambowitz AM. Structural basis of the evolution of a domesticated group II intron-like reverse transcriptase to function in host cell DNA repair. Biochemistry. 2025 July 29; 12231):e2504208122. Download Citation

Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers

Tagged With: 2024

Citation: Yao J, Xu H, Ferrick-Kiddie EA, Nottingham RM, Wu DC, Ares M, Lambowitz AM. Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers. PloS Genet. 2024 Sep 26; 20(9):e1011416 185 (20) :3671-3688. Download Citation

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