Publications

Citation:

Park SK, Guo M, Stamos JL, Wantae K, Lee S, Zhang YJ, Lambowitz AM. Structural basis of the evolution of a domesticated group II intron-like reverse transcriptase to function in host cell DNA repair. Biochemistry. 2025 July 29; 12231):e2504208122.

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Yao J, Xu H, Ferrick-Kiddie EA, Nottingham RM, Wu DC, Ares M, Lambowitz AM. Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers. PloS Genet. 2024 Sep 26; 20(9):e1011416 185 (20) :3671-3688.

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Cui H, Diedrich JK, Wu DC, Lim JJ, Nottingham RM, Moresco JJ, Yates JR, Blencowe BJ, Lambowitz AM, Schimmel P. Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2. Nature Cell Biology [Internet]. 25 :592–603.

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cui_2023.pdf

10.53 MB

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News & views highlight:

Arginyl-tRNA synthetase in inflammation. Nature Cell Biology, 25, 520-521, 2023.

Last updated on 11/15/2023

Citation:

Park SK, Mohr G, Yao J, Russell R, Lambowitz AM. Group II-like Reverse Transcriptases Function in Double Strand Break Repair. Cell [Internet]. 185 (20) :3671-3688.

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park_cell_2022.pdf

12.54 MB

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Cell Leading Edge Highlight:

Moran, J.V. and Wilson, T.E. Reverse transcriptase meets DNA, again: Possible roles for transposable elements in host DNA repair. Cell 185, 3643-3645, 2022.

Last updated on 11/15/2023

Citation:

Yao J, Wu DC, Nottingham RM, Lambowitz AM. Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling. eLife [Internet].

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Last updated on 09/15/2020

Citation:

Lentzsch AM, Yao J, Russell R, Lambowitz AM. Template switching mechanism of a group II intron-encoded reverse transcriptase and its implications for biological function and RNA-Seq. Journal of Biological Chemistry [Internet].

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lentzsch_2019.pdf

4.57 MB

Last updated on 01/22/2020

Citation:

Belfort M, Lambowitz AM. Group II Intron RNPs and ReverseTranscriptases: From Retroelements to Research Tools. Cold Spring Harbor Perspective in Biology [Internet].

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belfort_2019.pdf

2.83 MB

Last updated on 06/12/2019

Citation:

Xu H, Yao J, Wu DC, Lambowitz AM. Improved TGIRT-seq methods for comprehensive transcriptome profiling with decreased adapter dimer-formation and bias correction. Scientific Reports [Internet]. 9 (1).

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xu_2019.pdf

4.86 MB

Last updated on 06/11/2019

Citation:

Mohr G, Silas S, Stamos J, Makarova KS, Markham LM, Yao J, Lucas-Elio P, Sanchez-Amat A, Fire AZ, Koonin EV, et al. A Reverse Transcriptase-Cas1 Fusion Protein Contains a Cas6 Domain Required for Both CRISPR RNA Biogenesis and RNA Spacer Acquisition. Mol. Cell [Internet]. (72) :700-714.

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mohr_2018.pdf

4.33 MB

Last updated on 06/11/2019

Citation:

Boivin V, Deschamps-Francoeur G, Couture S, Nottingham RM, Bouchard-Bourelle P, Lambowitz AM. Simultaneous sequencing of coding and noncoding RNA reveals a human transcriptome dominated by a small number of highly expressed noncoding genes. RNA [Internet]. 24 (7) :950-965.

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boivin_2018.pdf

3.85 MB

Last updated on 07/30/2018