Selected Publications (2018-2024):
2024
Blednov YA, Shawlot W, Homanics GE, Osterndorff-Kahanek EA, Mason S, Mayfield
J, Smalley JL, Moss SJ, Messing RO. The PDE4 inhibitor apremilast modulates
ethanol responses in Gabrb1-S409A knock-in mice via PKA-dependent and
independent mechanisms. Neuropharmacology. 2024 Oct 1;257:110035. doi:
10.1016/j.neuropharm.2024.110035. Epub 2024 Jun 13. PMID: 38876310; PMCID:
PMC11387004.
Cruz B, Vozella V, Borgonetti V, Bullard R, Bianchi PC, Kirson D, Bertotto
LB, Bajo M, Vlkolinsky R, Messing RO, Zorrilla EP, Roberto M. Chemogenetic
inhibition of central amygdala CRF-expressing neurons decreases alcohol intake
but not trauma-related behaviors in a rat model of post-traumatic stress and
alcohol use disorder. Mol Psychiatry. 2024 Sep;29(9):2611-2621. doi:
10.1038/s41380-024-02514-8. Epub 2024 Mar 21. PMID: 38509197; PMCID:
PMC11415545.
Dilly GA, Blednov YA, Warden AS, Ezerskiy L, Fleischer C, Plotkin JD, Patil
S, Osterndorff-Kahanek EA, Mayfield J, Mayfield RD, Homanics GE, Messing RO.
Knockdown of Tlr3 in dorsal striatum reduces ethanol consumption and acute
functional tolerance in male mice. Brain Behav Immun. 2024 May;118:437-448. doi:
10.1016/j.bbi.2024.03.021. Epub 2024 Mar 16. PMID: 38499210; PMCID: PMC11007683.
Dugan MP, Maiya R, Fleischer C, Bajo M, Snyder AE, Koduri A, Srinivasan S,
Roberto M, Messing RO. Brain-specific serine/threonine-protein kinase 1 is a
substrate of protein kinase C epsilon involved in sex-specific ethanol and
anxiety phenotypes. Addict Biol. 2024 Mar;29(3):e13388. doi: 10.1111/adb.13388.
PMID: 38497285; PMCID: PMC10950061.
De Kraker H, Wang HL, Arman HD, Renteria RN, Fleischer CN, Messing RO,
McHardy SF. Asymmetric Synthesis of CIDD-0072424 via an Enantioselective Nitro-
Mannich Reaction: A Central Nervous System Penetrant, Selective Small Molecule
Inhibitor of Protein Kinase C Epsilon. J Org Chem. 2024 Apr 5;89(7):5134-5141.
doi: 10.1021/acs.joc.3c02917. Epub 2024 Mar 15. PMID: 38489762.
2023
Paliarin F, Duplantis C, Jones AF, Cucinello-Ragland J, Basavanhalli S, Blaze
E, Doré E, Neel AI, Sun H, Chen R, Edwards S, Gilpin NW, Messing RO, Maiya R. A
Cre Driver Line for Genetic Targeting of Kappa Opioid Receptor Expressing Cells.
eNeuro. 2023 Jul 13;10(7):ENEURO.0043-23.2023. doi: 10.1523/ENEURO.0043-23.2023. PMID: 37364995; PMCID: PMC10348446.
Dugan MP, Ferguson LB, Hertz NT, Chalkley RJ, Burlingame AL, Shokat KM,
Parker PJ, Messing RO. Chemical Genetic Identification of PKC Epsilon Substrates
in Mouse Brain. Mol Cell Proteomics. 2023 Apr;22(4):100522. doi:
10.1016/j.mcpro.2023.100522. Epub 2023 Feb 28. PMID: 36863607; PMCID:
PMC10105488.
Blednov YA, Da Costa A, Mason S, Mayfield J, Messing RO. Selective PDE4B and
PDE4D inhibitors produce distinct behavioral responses to ethanol and GABAergic
drugs in mice. Neuropharmacology. 2023 Jun 15;231:109508. doi:
10.1016/j.neuropharm.2023.109508. Epub 2023 Mar 18. PMID: 36935006; PMCID:
PMC10127528.
Zhao P, Mondal S, Martin C, DuPlissis A, Chizari S, Ma KY, Maiya R, Messing RO, Jiang N, Ben-Yakar A. Femtosecond laser microdissection for isolation of regenerating C. elegans neurons for single-cell RNA sequencing. Nat Methods. 2023 Apr;20(4):590-599. doi: 10.1038/s41592-023-01804-3. Epub 2023 Mar 16. PMID: 36928074.
2022
Ferguson LB, Mayfield RD, Messing RO. RNA biomarkers for alcohol use disorder. Front Mol Neurosci. 2022 Nov 4;15:1032362. doi: 10.3389/fnmol.2022.1032362. PMID: 36407766; PMCID: PMC9673015.
Blednov YA, Da Costa A, Mason S, Mayfield J, Moss SJ, Messing RO. Apremilast-induced increases in acute ethanol intoxication and decreases in ethanol drinking in mice involve PKA phosphorylation of GABA-A β3 subunits. Neuropharmacology. 2022 Dec 1;220:109255. doi: 10.1016/j.neuropharm.2022.109255. Epub 2022 Sep 21. PMID: 36152689.
Dilly GA, Kittleman CW, Kerr TM, Messing RO, Mayfield RD. Cell-type specific changes in PKC-delta neurons of the central amygdala during alcohol withdrawal. Transl Psychiatry. 2022 Jul 20;12(1):289. doi: 10.1038/s41398-022-02063-0. PMID: 35859068; PMCID: PMC9300707.
Ferguson LB, Roberts AJ, Mayfield RD, Messing RO. Blood and brain gene expression signatures of chronic intermittent ethanol consumption in mice. PLoS Comput Biol. 2022 Feb 17;18(2):e1009800. doi: 10.1371/journal.pcbi.1009800. PMID: 35176017; PMCID: PMC8853518.
Carmack SA, Vendruscolo JCM, Adrienne McGinn M, Miranda-Barrientos J, Repunte-Canonigo V, Bosse GD, Mercatelli D, Giorgi FM, Fu Y, Hinrich AJ, Jodelka FM, Ling K, Messing RO, Peterson RT, Rigo F, Edwards S, Sanna PP, Morales M, Hastings ML, Koob GF, Vendruscolo LF. Corticosteroid sensitization drives opioid addiction. Mol Psychiatry. 2022 May;27(5):2492-2501. doi: 10.1038/s41380-022-01501-1. Epub 2022 Mar 16. PMID: 35296810.
2021
Borghese CM, Wang HL, McHardy SF, Messing RO, Trudell JR, Harris RA, Bertaccini EJ. Modulation of α1β3γ2 GABA-A receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2008178118. doi: 10.1073/pnas.2008178118. PMID: 33593898; PMCID: PMC7923644.
He Y, Shi Z, Kashyap Y, Messing RO, Wang ZJ. Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice. Pain. 2021 Oct 1;162(10):2499-2511. doi: 10.1097/j.pain.0000000000002353. PMID: 34108435; PMCID: PMC8448952.
Domi E, Xu L, Toivainen S, Nordeman A, Gobbo F, Venniro M, Shaham Y, Messing RO, Visser E, van den Oever MC, Holm L, Barbier E, Augier E, Heilig M. A neural substrate of compulsive alcohol use. Sci Adv. 2021 Aug 18;7(34):eabg9045. doi: 10.1126/sciadv.abg9045. PMID: 34407947; PMCID: PMC8373126
2020
Blednov YA, Borghese CM, Dugan MP, Pradhan S, Thodati TM, Kichili NR, Harris RA, Messing RO. Apremilast regulates acute effects of ethanol and other GABAergic drugs via protein kinase A-dependent signaling. Neuropharmacology. 2020 Jul 28:108220. doi: 10.1016/j.neuropharm.2020.108220. Epub ahead of print. PMID: 32736086.
Blednov YA, Da Costa A, Mayfield J, Harris RA, Messing RO. Deletion of Tlr3 reduces acute tolerance to alcohol and alcohol consumption in the intermittent access procedure in male mice. Addict Biol. 2020 Jun 30:e12932. doi: 10.1111/adb.12932. Epub ahead of print. PMID: 32604471.
Venniro M, Russell TI, Ramsey LA, Richie CT, Lesscher HMB, Giovanetti SM, Messing RO, Shaham Y. Abstinence-dependent dissociable central amygdala microcircuits control drug craving. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):8126-8134. doi: 10.1073/pnas.2001615117. Epub 2020 Mar 23. PMID: 32205443; PMCID: PMC7148559.
Maiya R, Pomrenze MB, Tran T, Tiwari GR, Beckham A, Paul MT, Mayfield RD, Messing RO. Differential regulation of alcohol consumption and reward by the transcriptional cofactor LMO4. Mol Psychiatry. 2020 Mar 6. doi: 10.1038/s41380-020-0706-8. Epub ahead of print. PMID: 32144357.
2019
Ferguson LB, Patil S, Moskowitz BA, Ponomarev I, Harris RA, Mayfield RD, Messing RO. A Pathway-Based Genomic Approach to Identify Medications: Application to Alcohol Use Disorder. Brain Sci. 2019 Dec 16;9(12):381. doi: 10.3390/brainsci9120381. PMID: 31888299; PMCID: PMC6956180.
Pomrenze MB, Giovanetti SM, Maiya R, Gordon AG, Kreeger LJ, Messing RO. Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRFNeurons in Anxiety and Fear Learning. Cell Rep. 2019 Oct 1;29(1):13-21.e4. doi: 10.1016/j.celrep.2019.08.083. PubMed PMID: 31577943
Wang J, Blasio A, Chapman HL, Doebelin C, Liaw V, Kuryatov A, Giovanetti SM, Lindstrom J, Lin L, Cameron MD, Kamenecka TM, Pomrenze MB, Messing RO. Promoting activity of (α4)(3)(β2)(2) nicotinic cholinergic receptors reduces ethanol consumption. Neuropsychopharmacology. 2019 Aug 8. doi: 10.1038/s41386-019-0475-8. PubMed PMID: 31394567.
de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 2019 Mar 18;10(1):1238. doi: 10.1038/s41467-019-09183-0. PubMed PMID: 30886240
2018
Pomrenze MB, Tovar-Diaz J, Blasio A, Maiya R, Giovanetti SM, Lei K, Morikawa H, Hopf FW, Messing RO. A Corticotropin releasing factor network in the extended amygdala for anxiety. J Neurosci 2018 Dec 10. pii: 2143-18. doi: 10.1523/JNEUROSCI.2143-18.2018. PubMed PMID: 30530860.
Warden AS, Azzam MM, DaCosta A, Mason S, Blednov YA, Messing RO, Dayne Mayfield R, Adron Harris R. Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice. Brain Behav Immun. 2018 Dec 11. pii: S0889-1591(18)30386-6. doi: 10.1016/j.bbi.2018.12.004. PubMed PMID: 30550931.
Warden AS, Azzam M, DaCosta A, Mason S, Blednov YA, Messing RO, Mayfield RD, Harris RA. Toll-like receptor 3 dynamics in female C57BL/6J mice: Regulation of alcohol intake. Brain Behav Immun. 2018 Dec 11. pii: S0889-1591(18)30387-8. doi: 10.1016/j.bbi.2018.12.006. PubMed PMID: 30550930.
YA, Da Costa AJ, Tarbox T, Ponomareva O, Messing RO, Harris RA. Apremilast alters behavioral responses to ethanol in mice: I. Reduced consumption and preference. Alcohol Clin Exp Res. 42(5):926-938, 2018. PMCID: PMC5915912.
Blednov YA, Da Costa AJ, Harris RA, Messing RO. Apremilast alters behavioral responses to ethanol in mice: II. Increased sedation, intoxication, and reduced acute functional tolerance. Alcohol Clin Exp Res. 42(5):939-951, 2018. PMCID: PMC5916327.
Blasio A, Wang J, Wang D, Varodayan FP, Pomrenze MB, Miller J, Lee AM, McMahon T, Gyawali S, Wang HY, Roberto M, McHardy S, Pleiss MA, Messing RO. Novel small-molecule inhibitors of protein kinase C epsilon reduce ethanol consumption in mice. Biol Psychiatry. 84(3):193-201, 2018. PMCID: PMC5984071.