Current Projects

  • Developing PKC epsilon inhibitors to reduce chronic pain and alcohol consumption.
  • Identifying drug targets in PKC epsilon signaling pathways using ATP analog-specific kinase technology.
  • Transcriptional profiling to repurpose drugs for treating substance use disorders.
  • Identifying drug targets within neuroimmune pathways activated by chronic alcohol exposure.
  • Identifying circuits in the extended amygdala that regulate anxiety, fear and excessive alcohol consumption.
CRF neurons of the central amygdala differentially regulate fear and anxiety through the release of GABA and different neuropeptides (Pomrenze et al, Cell Reports 2019).