Clinical Applications

Clinical Applications

The information provided by image processing derived functional inference methods, such as CT-derived functional imaging, can be used to 1) detect the presence of disease, 2) quantify disease severity and progression, 3) evaluate treatment effectiveness, and within the context of cancer radiotherapy, radiation-induced injury. The figure above uses CTFI methods to illustrate the disease progression of interstitial pulmonary fibrosis.

Selected Publications on Clinical Applications

1. Yevgeniy Vinogradskiy, Richard Castillo, Edward Castillo, Leah Schubert, Bernard Jones, Austin Faught, Laurie Gaspar, Jennifer Kwak, Daniel Bowles, Timothy Waxweiler, Jing Jingjing Dougherty, Dexiang Gao, Craig Stevens, Moyed Miften, Brian Kavanagh, Inga Grills, Chad Rusthoven, and Thomas Guerrero. Results of a Multi-Institutional Phase II Clinical Trial for 4DCT-Ventilation Functional Avoidance Thoracic Radiotherapy, International Journal of Radiation Oncology, Biology, Physics. In Press, 2021.
   
   
2. Filip Ionescu, Markie Zimmer, Ioana Petrescu, Edward Castillo, Paul Bozyk, Amr Abbas, Lauren Abplanlb, Sanjay Dogra, and Girish Nair. Extubation Failure in Critically Ill COVID-19 Patients: Risk Factors and Impact on In-Hospital Mortality. Journal of Intensive Care Medicine,36(9): 1018-1024, 2021.
   
   
3. Girish Nair, Sayf Al-Katib, Danielle Turner-Lawrence, Majd Khasawneh, Nicholas Myziuk, Thomas Guerrero, Robert Podolsky, and Edward Castillo. A Prospective Study to Characterize Pulmonary Blood Mass Changes on Non-Contrast 4DCT in Pulmonary Embolism Patients. Clinical Imaging, 78: 179-183, 2021.
   
   
4. Girish Nair, Sayf Al-Katib, and Edward Castillo. Pulmonary Blood Mass and Quantitative Lung Function Imaging in Idiopathic Pulmonary Fibrosis. Radiology: Cardiothoracic Imaging, 2(3): e200003, 2020.
   
   
5. Girish Nair, Edward Castillo, Nicholas Myziuk, Inga Grills, Craig Stevens, and Thomas Guerrero. Differential Ventilation Pattern on Novel Functional Imaging in a Patient with Unilateral Bronchial Obstruction Caused by Adenoid Cystic Carcinoma. American Journal of Respiratory and Critical Care Medicine. In Press, 2019.
   
   
6. Girish Nair and Edward Castillo. Longitudinal Lung Compliance Imaging in Idiopathic Pulmonary Fibrosis. Radiology. 293(2): 272-272, 2019.
   
   
7. Yevgeniy Vinogradskiy, Chad Rusthoven, Leah Schubert, Bernard Jones, Austin Faught, Richard Castillo, Edward Castillo, Laurie Gaspar, Jennifer Kwak, Timothy Waxweiler, Michele Dougherty, Dexiang Gao, Craig Stevens, Moyed Miften, Brian Kavanagh, Thomas Guerrero, and Inga Grills. Interim Analysis of a Two Institution, Prospective, Clinical Trial of 4DCT-Ventilaiton-Based Functional Avoidance Radiation Therapy. International Journal of Radiation Oncology, Biology, Physics, 102(4): 1357-1365, 2018.
   
   
8. Austin Faught, Tokihiro Yamamoto, Richard Castillo, Edward Castillo, Jingjing Zhang, Moyed Miften, and Yevgeniy Vinogradskiy. Evaluating which Dose-Function Metrics are Most Critical for Functional-Guided Radiotherapy with CT Ventilation Imaging. International Journal of Radiation Oncology, Biology, Physics, 99(1): 202-209, 2017.
   
   
9. Yevgeniy Vinogradskiy, Matthew Jackson, Leah Schubert, Bernard Jones, Richard Castillo, Edward Castillo, Thomas Guerrero, John Mitchell, Chad Rusthoven, Moyed Miften, and Brian Kavanagh. Assessing the Use of 4DCT-Ventilation in Pre-operative Surgical Lung Cancer Evaluation. Medical Physics, 44(1): 200-208, 2016.
   
   
10. Richard Castillo, Ngoc Pham, Edward Castillo, Samantha Aso-Gonzalez, Sobiya Ansari, Brian Hobbs, Diana Palacio, Heath Skinner, and Thomas Guerrero. Pre–Radiation Therapy Fluorine 18 Fluorodeoxyglucose PET Helps Identify Patients with Esophageal Cancer at High Risk for Radiation Pneumonitis. Radiology, 275(3): 822-831, 2015.