Clinical Applications

Clinical Applications

The information provided by image processing derived functional inference methods, such as CT-derived functional imaging, can be used to 1) detect the presence of disease, 2) quantify disease severity and progression, 3) evaluate treatment effectiveness, and within the context of cancer radiotherapy, radiation-induced injury. The figure above uses CTFI methods to illustrate the disease progression of interstitial pulmonary fibrosis. The lab applies these ideas to other clinical applications, including cardiac mechanics and neuroimaging.

Selected Publications on Clinical Applications

Hsu-Ting Kuo, Yi-Kuan Liu, Debarghya Chaki, Girish Nair, Danielle Turner-Lawrence, Craig Stevens, Jorge Cisneros and Edward Castillo. Diagnoses of Pulmonary Embolism from Non-Contrast 4DCT Using Image Processing-Derived Quantitative Perfusion Scores. npj Biomedical Innovations. In Press, 2026.

Jorge Cisneros, Caleb J. Herrera, Yi-Kuan Liu, Lisa V. Du, Yevgeniy Vinogradskiy, Richard Castillo, Girish Nair, and Edward Castillo. Clinical Validation of Perfusion Imaging with Pulmonary Function Test Data Using Voronoi-Based Discretization. Physics in Medicine and Biology. 71:055004, 2026.

Julian Weaver, Emerald Zhang, Nihita Sarma, Alaa Melek and Edward Castillo. Explainable Schizophrenia Classification from rs-fMRI using SwiFT and TransLRP. Algorithms, 18 (11): 701, 2025.

Girish Nair, Yuying (Judy) Xing, Aaron Luong, Faiza Bashar, Amanda Nowacki, Craig Stevens, Lili Zhao and Edward Castillo. CT-Derived Functional Imaging Biomarkers Combined with FEV1 for Predicting 10-year All-Cause Mortality in COPDGene Cohort. npj Biomedical Innovations. 2: 25, 2025.

Devansh Pandey, Liaoyi Xu, Eucharist Kun, Joyce Wang, Chenfei Li, Alaa Melek, Julie DiCarlo, Edward Castillo, Jagat Narula, Charles Taylor and Vagheesh Narasimhan. Multimodal AI for Precision Preventive Cardiology. medRxiv 2025.10.09.25337677, 2025.

Yevgeniy Vinogradskiy, Richard Castillo, Edward Castillo, Leah Schubert, Bernard Jones, Austin Faught, Laurie Gaspar, Jennifer Kwak, Daniel Bowles, Timothy Waxweiler, Jing Jingjing Dougherty, Dexiang Gao, Craig Stevens, Moyed Miften, Brian Kavanagh, Inga Grills, Chad Rusthoven, and Thomas Guerrero. Results of a Multi-Institutional Phase II Clinical Trial for 4DCT-Ventilation Functional Avoidance Thoracic Radiotherapy, International Journal of Radiation Oncology, Biology, Physics. 112(4): 986 – 995, 2022.

Filip Ionescu, Markie Zimmer, Ioana Petrescu, Edward Castillo, Paul Bozyk, Amr Abbas, Lauren Abplanlb, Sanjay Dogra, and Girish Nair. Extubation Failure in Critically Ill COVID-19 Patients: Risk Factors and Impact on In-Hospital Mortality. Journal of Intensive Care Medicine,36(9): 1018-1024, 2021.