Vijay Rajagopal Institute: University of Melbourne Date: January 30, 2025 Title: Harnessing AI for biological microscopy image segmentation Abstract: The Cell Systems and Mechanobiology Lab at the University of Melbourne is developing computational methods and mathematical models to construct a virtual model of living cell physiology to understand disease mechanisms and computationally find novel therapeutic targets. A first step towards creating a virtual living cell model is to process biological microscopy images to reconstruct an accurate 3D geometric model of the cell interior. But this step is not as easy as it may seem when one considers image properties, the crowded nature of the cell interior, the variability in anatomical structure between cells, and the size of the microscopy data produced today. In this talk, I will introduce listeners to the unique challenges that microscopy data present to image processing and present our experience in addressing these challenges as we harness AI to accelerate our research towards a virtual model of living cell physiology.
