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Lambowitz Lab
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  • Research Summary
    • (A) Mobile Group II Intron, Evolutionary Ancestors of Retroviruses, Retrotransposons, and Spliceosomal Introns in Eukaryotes.
    • (B) Group II Intron Reverse Transcriptases
    • (C) Reverse Transcriptases Associated with CRISPR-Cas Systems and Other Bacterial and Organellar Reverse Transcriptases
    • (D) Thermostable Group II Intron Reverse Transcriptases (TGIRTs) and Their Applications in High Throughput RNA Sequencing (RNA-Seq).
    • (E) Analysis of Extracellular RNAs, RNA Diagnostics, and Liquid Biopsy and tRNA fragments
  • People
    • Principal Investigator
    • Assistant to Dr. Lambowitz
    • Postdoctoral Associates
    • Research Engineering/Scientist Associates
    • Research Associates
    • Graduate Students
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Lambowitz Lab

Department of Molecular Biosciences

100 East 24th St., Stop A5000
Austin, TX 78712 (email)

Publications

December 13, 2024, Filed Under: Publications

Toward a molecular understanding of RNA remodeling by DEAD-box proteins.

Citation:

Russell R, Jarmoskaite I, Lambowitz AM. Toward a molecular understanding of RNA remodeling by DEAD-box proteins. RNA Biol [Internet]. 10 (1) :44-55.

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Last updated on 02/12/2015

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December 13, 2024, Filed Under: Publications

The retrohoming of linear group II intron RNAs in Drosophila melanogaster occurs by both DNA ligase 4-dependent and -independent mechanisms.

Citation:

White TB, Lambowitz AM. The retrohoming of linear group II intron RNAs in Drosophila melanogaster occurs by both DNA ligase 4-dependent and -independent mechanisms. PLoS Genet. 8 (2) :e1002534.

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December 13, 2024, Filed Under: Publications

Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p.

Citation:

Mallam AL, Del Campo M, Gilman B, Sidote DJ, Lambowitz AM. Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p. Nature. 490 (7418) :121-5.

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December 13, 2024, Filed Under: Publications

ATP-dependent roles of the DEAD-box protein Mss116p in group II intron splicing in vitro and in vivo.

Citation:

Potratz JP, Del Campo M, Wolf RZ, Lambowitz AM, Russell R. ATP-dependent roles of the DEAD-box protein Mss116p in group II intron splicing in vitro and in vivo. J Mol Biol. 411 (3) :661-79.

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December 13, 2024, Filed Under: Publications

Group II introns: mobile ribozymes that invade DNA.

Citation:

Lambowitz AM, Zimmerly S. Group II introns: mobile ribozymes that invade DNA. Cold Spring Harb Perspect Biol. 3 (8) :a003616.

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December 13, 2024, Filed Under: Publications

High-throughput genetic identification of functionally important regions of the yeast DEAD-box protein Mss116p.

Citation:

Mohr G, Del Campo M, Turner KG, Gilman B, Wolf RZ, Lambowitz AM. High-throughput genetic identification of functionally important regions of the yeast DEAD-box protein Mss116p. J Mol Biol. 413 (5) :952-72.

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December 13, 2024, Filed Under: Publications

NMR Structure of the C-terminal domain of a tyrosyl-tRNA synthetase that functions in group I intron splicing.

Citation:

Paukstelis PJ, Chari N, Lambowitz AM, Hoffman D. NMR Structure of the C-terminal domain of a tyrosyl-tRNA synthetase that functions in group I intron splicing. Biochemistry. 50 (18) :3816-26.

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December 13, 2024, Filed Under: Publications

Solution structures of DEAD-box RNA chaperones reveal conformational changes and nucleic acid tethering by a basic tail.

Citation:

Mallam AL, Jarmoskaite I, Tijerina P, Del Campo M, Seifert S, Guo L, Russell R, Lambowitz AM. Solution structures of DEAD-box RNA chaperones reveal conformational changes and nucleic acid tethering by a basic tail. Proc Natl Acad Sci U S A. 108 (30) :12254-9.

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December 13, 2024, Filed Under: Publications

Genetic identification of potential RNA-binding regions in a group II intron-encoded reverse transcriptase.

Citation:

Gu S-Q, Cui X, Mou S, Mohr S, Yao J, Lambowitz AM. Genetic identification of potential RNA-binding regions in a group II intron-encoded reverse transcriptase. RNA. 16 (4) :732-47.

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December 13, 2024, Filed Under: Publications

Mechanisms used for genomic proliferation by thermophilic group II introns.

Citation:

Mohr G, Ghanem E, Lambowitz AM. Mechanisms used for genomic proliferation by thermophilic group II introns. PLoS Biol. 8 (6) :e1000391.

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Recent Publications

Real-Time Visualization of G2L4 Reverse Transcriptase in DNA Repair via Microhomology- Mediated End Joining

Citation: Zhang P, Guo M, Zhang YJ, Lambowitz AM, Lin YC. Real-Time Visualization of G2L4 Reverse Transcriptase in DNA Repair via Microhomology-Mediated End Joining. bioRxiv [Preprint]. 2026 Mar 17:2026.03.13.711756. doi: 10.64898/2026.03.13.711756. PMID: 41890004; PMCID: PMC13015716.

RNASET2 degrades mRNAs that protect against lipotoxicity

Citation: Shuiling Zhao, Stevens Bontemps, Ryan M. Nottingham, Jun Yao, Mariana Acuña, David E. Cohen, Alan M. Lambowitz, Jean E. Schaffer, Molecular Metabolism, Vol 110, 2026, 102409, ISSN 2212-8778, https://doi.org/10.1016/j.molmet.2026.102409.

Pervasive enhanced transcription in inflammatory breast cancer tumors and PBMCs impacts RNA splicing and intronic RNAs in plasma

Citation: Dennis Wylie et al. ,Pervasive enhanced transcription in inflammatory breast cancer tumors and PBMCs impacts RNA splicing and intronic RNAs in plasma.Sci. Adv.12, eadu0031(2026).DOI:10.1126/sciadv.adu0031

Structural basis for the evolution of a domesticated group II intron–like reverse transcriptase to function in host cell DNA repair

Tagged With: 2025

Citation: Park SK, Guo M, Stamos JL, Wantae K, Lee S, Zhang YJ, Lambowitz AM. Structural basis of the evolution of a domesticated group II intron-like reverse transcriptase to function in host cell DNA repair. Biochemistry. 2025 July 29; 12231):e2504208122. Download Citation

Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers

Tagged With: 2024

Citation: Yao J, Xu H, Ferrick-Kiddie EA, Nottingham RM, Wu DC, Ares M, Lambowitz AM. Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers. PloS Genet. 2024 Sep 26; 20(9):e1011416 185 (20) :3671-3688. Download Citation

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