Publications

2021

• S. Stanford#, M. Collins#, M. Diaz, Z. Holmes, P. Gries, M. Bliss, A. Lodi, V. Zhang, S. Tiziani*, N. Bottini* “The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy”, Journal of Cellular Physiology (Accepted, 2021, #equal contribution first authors, *equal contribution corresponding authors)

2020

• G. L. Hackman, M. Collins, X. Lu, A. Lodi, J. DiGiovanni, S. Tiziani “Predicting and quantifying antagonistic effects of natural compounds given with chemotherapeutic agents: Applications for high throughput-screening”, Cancers, 12(12), 3714 (2020)
• A. Kosti, P. Rosa de Araujo, W.-Q. Li, G. Guardia, J. Chiou, C. Yi, D. Ray, F. Meliso, Y.-M. Li, T. Delambre, M. Qiao; S. S. Burns; F. K. Lorbeer, F. Georgi, M. Flosbach, S. Klinnert, A. Jennseit, X. Lei, C. R. Sandoval, K. Ha, H. Zheng, R. Pandey, A. Gruslova, Y. Gupta; A. Brenner, E. Kokovay, T. R Hughes; Q. Morris, P. Galante, S. Tiziani*, L. O F Penalva* “The RNA binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging “cancer metabolism” and epigenetic regulation”, Genome Biology, 6;21(1):195  (2020; *equal contribution corresponding authors)
• F. Choudhury, G. L. Hackman, A. Lodi, S. Tiziani “Stable isotope tracing metabolomics to investigate the metabolic activity of bioactive compounds for cancer prevention and treatment”, Cancers, 3;12(8):E2147 (2020)
• C. Lu, A. Saha, W. Yan, K. Garrison, C. Lamb, R. Pandey, S. Irani, A. Lodi, X. Lu, S. Tiziani, Y. Zhang, G. Georgiou, J. DiGiovanni, E. Stone “Enzyme-Mediated Depletion of Serum L-Met Abrogates Prostate Cancer Growth via Multiple Mechanisms without Evidence of Systemic Toxicity” PNAS, 117 (23), 13000-13011 (2020)
• S.R. Sweeney, M. Collins, R. Pandey, J. Chiou, A. Lodi, S. Tiziani “Identification of a synergistic combination of dimethylaminoparthenolide and shikonin alters metabolism and inhibits proliferation of pediatric precursor-B cell acute lymphoblastic leukemia” Molecular Carcinogenesis, 59(4), 399-411 (2020)
• R. Pandey, A. Gruslova, J. Chiou, A. J. Brenner, S. Tiziani “Stable Isotope Dilution LC-HRMS Assay to Determine Free SN-38, Total SN-38, and SN-38G in Tumor Xenograft Model after Intravenous Administration of Antibody-Drug Conjugate (Sacituzumab govitecan)” Analytical Chemistry, 92, 1260-1267 (2020)

2019

• M. D. Peris-Díaz, S. R. Sweeney, O. Rodak, E. Sentandreu, S. Tiziani “R-MetaboList 2: a flexible tool for metabolite annotation from high-resolution data-independent acquisition mass spectrometry analysis” Metabolites, 9(9), 187 (2019)
• X. Lu, A. Lodi, M. Konopleva, S. Tiziani “Three-dimensional leukemia co-culture system for in vitro high-content metabolomics screening” SLAS Discovery, 24(8), 817-828 (2019)
• S. Kshattry, A. Saha, P. Gries, S. Tiziani, E. Stone, G. Georgiou, J. DiGiovanni “Targeting antioxidant pathways for suppression of pancreatic tumor growth” Npj Precision Oncology (2019)
• E. Sanchez-Lopez, Z. Zhong, A. Stubelius, S. R. Sweeney, L. M. Booshehri, L. Antonucci, R. Liu-Bryan, A. Lodi, R. Terkeltaub, J. C. Lacal, A. N. Murphy, H. M. Hoffman, S. Tiziani, M. Guma, M. Karin “Choline uptake and metabolism modulate macrophage IL-1β and IL-18 production” Cell Metabolism, 29, 1-13 (2019)

2018

• A. Triplett, K. C. Garrison, N. Marshall, M. Donkor, J. Blazeck, C. Lamb, A. Qerqez, J. Dekker, Y. Tano, W.-Ch. Lu, C. S. Karamitros, K. Ford, B. Tan, M. Zhang, K. McGovern, S. Coma, Y. Kumada, M. S. Yemeny, E. Sentandreu, G. Fromm, S. Tiziani, T. H. Schreiber, M. Manfredi, L. I. R. Ehrlich, E. Stone and G. Georgiou “Reversal of IDO-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme” Nature Biotechnology, 36, 758–764 (2018)
• R. Narasimhan, R. Coras, S. Rosenthal, S. Sweeney, A. Lodi, S. Tiziani, D. Boyle, A. Kavanaugh, M. Guma, “Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis” Arthritis Research & Therapy, 20, 164-175 (2018)
• J. R. Molina, Y. Sun, M. Protopopova, S. Gera_, M. Bandi, C. Bristow, T. McAfoos, P. Morlacchi, A.-N. A. Agip, G. Al-Atrash, J. Asara, J. Bardenhagen, C. C Carrillo, C. Carroll, E. Chang, S. Ciurea, J. B. Cross, B. Czako, A. Deem, N. Daver, J. Frederick de Groot, J.-W. Dong, N. Feng, G. Gao, J. Gay, M. Geck Do, J. Greer, J. Han, V. K Henry, J. Hirst, S. Huang, Y. Jiang, Z. Kang, S. Konoplev, G. Liu, A. Lodi, T. Lofton, H. Ma, P. Matre, R. Mullinax, M. Peoples, A. Petrocchi, J. Rodriguez-Canale, R. Serreli, T. Shi, M. Smith, J. Theroff, S. Tiziani, Q. Xu, Q. Zhang, F. Muller, R. A. DePinho, C. Toniatti, T. P. Heffernan, G. F. Draetta, M. Konopleva, P. Jones, M. E. Di Francesco and J. R. Marszalek, “An inhibitor of oxidative phosphorylation exploits cancer vulnerability” Nature Medicine, 24, 1036–1046 (2018)
• E. Sentandreu, M. Peris, S. R. Sweeney, J. Chiou, N. Muñoz, S. Tiziani, “A survey of Orbitrap All Ion Fragmentation analysis assessed by an R Metabolist Package to Study Small-molecule Metabolites” Chromatographia, 81(7), 981-994 (2018)
• J. Falconer, A. Murphy, S. Young, S. Tiziani, C. D. Buckley, and M. Guma, “Synovial cell metabolism and chronic inflammation in rheumatoid arthritis” Arthritis & Rheumatology, doi:10.1002/art.40504 (2018)
• R. Pandey, C.L. Riley, E. M. Mills, S. Tiziani, “Highly Sensitive and Selective Determination of Redox States of Coenzymes Q9 and Q10 in Mice Tissues: Application of Orbitrap Mass Spectrometry” Analytica Chimica Acta, 1011, 68-76 (2018)
• J. Bryant, S. Sweeney, E. Sentandreu, M. Shin, H. Ipas, B. Xhemalce, J. Momb, S. Tiziani, and D. Appling, “Deletion of the neural tube defect-associated gene Mthfd1l disrupts one-carbon and central energy metabolism in mouse embryos” Journal of Biological Chemistry, 293(16), 5821-5833 (2018)
• A. Brenner, J. Sun, J. Floyd, R. Zuniga, C. Hart, S. Kroll, L. Fichtel, D. Cavazos, L. Caflisch, A. Gruslova, A. Lodi, S. Tiziani, “Hypoxia Activated Evophosphamide for Treatment of Recurrent Bevacizumab-Refractory Glioblastoma: A phase I surgical study” Neuro-Oncology, https://doi.org/10.1093/neuonc/noy015 (2018)

2017

• J. Jose, C. D. J. Tavares, N. D. Ebelt, A. Lodi, R. Edupuganti, Xuemei Xie, A. K. Devkota, T. S. Kaoud, Carla L. Van Den Berg, E. V. Anslyn, S. Tiziani, C. Bartholomeusz, K. N. Dalby, “Serotonin Analogs as Inhibitors of Breast Cancer Cell Growth” ACS Medicinal Chemistry Letters, 8(10), 1072-1076 (2017)
• K. Lewis, S. Brown, S. Tiziani, R. Carrasco, “Sociocultural Considerations in Juvenile Arthritis: A Review”, Journal of Pediatric Nursing, 37, 13-21 (2017)
• R. Pandey, L. Caflisch, A. Lodi, A. J. Brenner, S. Tiziani, “Metabolomic signature of brain cancer” Molecular Carcinogenesis, 1-17 (2017)
• A. Lodi, A. Saha, X. Lu, B. Wang, E. Sentandreu, M. Collins, M. Kolonin, J. DiGiovanni and S. Tiziani “Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism” Npj Precision Oncology, 1:18 (2017)  
  Highlights:
  • College of Natural Sciences News: “Starving Prostate Cancer With What You Eat for Dinner“
  • College of Pharmacy News: “Starving cancer cells with combinations of natural compounds found in foods“
  • Downtown Austin Patch: “New UT-Austin Research IDs Compounds That Could Thwart Prostate Cancer“
• X. Lu, A. Solmonson, S. M. Nowinski, E. Sentandreu, A. Lodi, E. M. Mills, S. Tiziani, “The cold-induced early metabolomics response analysis of adipose tissue during acute cold exposure in mice” Scientific Reports, 7, 3455 (2017)
• S. L. Cramer, A. Saha, J. Liu, S. Tadi, S. Tiziani, W. Yan,K. Triplett, C. Lamb, S. E. Alters, S. Rowlinson, Y. J. Zhang, M. J.Keating, P. Huang, J. DiGiovanni, G. Georgiou, and E. Stone “Systemic depletion of serum L-Cyst(e)ine with an engineered human enzyme induces production of reactive oxygen species and suppresses tumor growth in mice” Nature Medicine, 23, 120-127 (2017)

2016

• P. Matre, J. Velez, R. Jacamo, Y.Qi, X. Su, T. Cai, S., Chan, A. Lodi, S. R. Sweeney, H.Ma, R. E. Davis, S. Schindela, T. Haferlach, X. Su, E. R. Flores, D.Gonzalez, S. Konoplev, I. Samudio, C. DiNardo, R. Majeti, A. D. Schimmer, W. Li, T. Wang, S. Tiziani, M. Konopleva “Inhibiting glutaminase in acute myeloid leukemia: Metabolic dependency of selective acute myeloid leukemia subtypes” Oncotarget, 7(48) 79722-79735 (2016)
• L. M. Lashinger, C. H. O’Flanagan, S. M. Dunlap, A. J. Rasmussen, S. Sweeney, J. Y. Guo, A. Lodi, S. Tiziani, E. White and S. D. Hursting, “Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors” Cancer & Metabolism, 4-18 (2016)
• S. R. Sweeney, A. Kavanaugh, A. Lodi, B. Wang, D. Boyle, S. Tiziani*, M. Guma*. “Metabolomic Profiling Predicts outcome of Rituximab therapy in Rheumatoid Arthritis.” Rheumatic and Musculoskeletal Diseases, 2(2) e000289 (2016; *equal contribution corresponding authors)
• M. Guma*, S. Tiziani*, and G. S. Firestein, “Metabolomics in Rheumatoid Arthritis: Desperately Seeking Biomarkers” Nature Reviews Rheumatology 12, 269-281(2016; *equal contribution first authors)
• R. Garcia-Carbonell, A.S. Divakaruni, A. Lodi, I. Vicente-Suarez, A. Saha, H. Cheroutre, G.R. Boss, S. Tiziani, A.N. Murphy, G.S. Firestein, M. Guma, “Critical role of fibroblast-like synoviocytes glycolytic metabolism in rheumatoid arthritis” Annals of the Rheumatic Diseases, 68(7) 1614-1626 (2016)

2015

• R. Sweeney, J. DiGiovanni, S. Tiziani, “Metabolomics, Bioactives, and Cancer.” Genomics, Proteomics, and Metabolomics in Neutraceuticals and Functional Foods (2nd edition), Ed. Bagchi D, Swaroop A, Bagchi M. John Wiley and Sons, West Sussex, United Kingdom. ISBN: 978-1-118-93042-7 (2015).
• M. Guma, E. Sanchez-Lopez, A. Lodi, R. Garcia-Carbonell, S. Tiziani, M. Karin, J. C. Lacal and G. S. Firestein, “Choline kinase inhibition in rheumatoid arthritis” Annals of the Rheumatic Diseases 74(7), 1399-1407 (2015)
• J. Purać, D. Kojić, Ž. Popović, E. Vukašinović, S. Tiziani, U. L. Günther, G. Grubor-Lajšić, “Metabolomic analysis of diapausing and non-diapausing larvae of European corn borer Ostrinia nubilalis” Acta Chimica Slovenica, 62(4), 761-767 (2015)

2014

• Y. Kang, S. Tiziani, G. Park, M. Kaul, G. Paternostro, “Protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity” Nature Communications, 5:3672 (2014)
• S. Tadi, S. Sweeney, S. Tiziani, “Future Perspectives of Metabolomics in Adipocytes” J. Nutrition Health Food Sci. 2(2): 1-7 (2014)

2013

• S. Tiziani*, Y. Kang, J. Axelrod, R. Harjanto, C. Piermarocchi, W. Roberts, G. Paternostro*, “Metabolomics of the tumor microenvironment in childhood lymphoblastic leukemia” PLoS ONE 8(12), e82859 (2013) (*equal contribution corresponding authors)
• A. Lodi*, S. Tiziani*, F. L. Khanim, U. L. Günther, M. R. Viant, C. M. Bunce, M. T. Drayson “Proton NMR-based metabolic analyses of MRC Myeloma IX serum samples identifies carnitine and acetyl carnitine as novel markers of active disease and demonstrate the value of non empirically presumed poor quality archived patient material” PLoS ONE 8(2), e56422 (2013) (*equal contribution)

2003-2012

• C. Ludwig, J. M. Easton, A. Lodi, S. Tiziani, S. Manzoor, A. D. Southam, J. Byrne, L. Bishop, S. He, T. N. Arvanitis, U. L. Günther, M. R. Viant “Birmingham Metabolite Library: A publicly accessible database of 1-D and 2-D ¹H J-resolved NMR spectra of authentic metabolite standards (BML-NMR)” Metabolomics, 8(1), 8-18 (2012)
• S. Tiziani, Y. Kang, S. Choi, W. Roberts, G. Paternostro, “Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library” Nature Communications, 2:545 (2011)
• A. Lodi*, S. Tiziani*, F. L. Khanim, M. T. Drayson, U. L. Günther, C. M. Bunce, M. R. Viant, “Hypoxia Triggers Major Metabolic Changes in AML Cells without Altering Indomethacin-Induced TCA Cycle Deregulation” ACS Chemical Biology 6(2), 169-175 (2011) (*equal contribution)
• A. Felluga and S. Tiziani, “Intensive natural distribution as Bernoulli success ratio extension to continuous: enhanced Gaussian, continuous Poisson, and phenomena explanation” (arXiv:1102.0625, 2011)
• F. L. Khanim, R. E. Hayden,J. Birtwistle, A. Lodi, S. Tiziani, N. J. Davies, J. P. Ride, M. R. Viant, U. L. Günther, J. C. Mountford, H. Schrewe, R. M. Green, J. A. Murray, M. T. Drayson and C. M. Bunce “Combined bezafibrate and medroxyprogesterone acetate: Potential novel therapy for acute myeloid leukaemia”PLoS ONE 4(12), e8147 (2009)
• H.M. Romanska*, S. Tiziani*, R. Howe, U. L. Günther, Z. Gulzar, E.-N. Lalani, “NMR detects PI3k/Akt independent Traits Common to Pluripotent Murine Embryonic Stem Cells and their Malignant Counterparts” Neoplasia, 11(12), 1301-1308 (2009) (*equal contribution)
• S. Tiziani, A. Lodi, F. L. Khanim, M. R. Viant, C. M. Bunce, U. L. Günther, “Metabolomic profiling of drug response in leukaemia cell lines” PLoS ONE 4(1), e4251 (2009)
• S. Tiziani, V. Lopes, U. L. Günther, “Early stage diagnosis of oral cancer using ¹H NMR-based metabolomics” Neoplasia, 11(3), 269-276 (2009)
• S. Tiziani, A-H. Emwas, A. Lodi, C. Ludwig, M. R. Viant, U. L. Günther. “Optimised Metabolite Extraction Blood Serum for ¹H Nuclear Magnetic Resonance Spectroscopy“ Analytical Biochemistry, 377(1),  16-23 (2008)
• S. Tiziani, A. Lodi, C. Ludwig, H. M. Parsons, and M. R. Viant “Effects of the application of different window functions and projection methods on processing of ¹H J-resolved nuclear magnetic resonance spectra for metabolomics” Analytica Chimica Acta, 610(1), 80-88 (2008)
• S. Tiziani, S. J. Schwartz, and Y. Vodovotz, “Intermolecular interactions in phytochemical model systems studied by NMR diffusion measurements” Food Chemistry, 107, 962-969 (2008)
• A. Lodi, S. Tiziani, and Y. Vodovotz,“Molecular changes in soy and wheat breads during storage as probed by NMR” Journal of Agricultural and Food Chemistry, 55, 5850-5857 (2007)
• S. Tiziani, S. J. Schwartz, and Y. Vodovotz, “Profiling of carotenoids in typical red tomato juice by one and two dimensional NMR” Journal of Agricultural and Food Chemistry, 54, 6094-6100 (2006)
• S. Tiziani and Y. Vodovotz, “Rheological studies of a novel functional food: tomato juice with soy germ” Journal of Agricultural and Food Chemistry, 53, 7267-7273 (2005)
• S. Tiziani and Y. Vodovotz, “Rheological effects of soy protein addition to tomato juice” Food Hydrocolloids, 19(1), 45-52 (2005)
• C. Bonutti, F. Sussich, S. Tiziani, and A. Cesàro, “Calorimetric study of the early stage of hyaluronan oxidation”. Chapter in Edited Book: Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications. Chapter 1: Structure of Hyaluronan and its Properties in Solution. Editors: E.A. Balazs and V.C. Hascall (2003)
• S. Tiziani, F. Sussich, and A. Cesàro, “The kinetic of periodate oxidation of carbohydrates 2. Polymeric substrates” Carbohydrate Research, 338, 1083-1095 (2003)