It has been commonly thought that children infected with SARS-CoV-2 rarely develop severe symptoms compared to adults. Although there have been a number of cases of Kawasaki-like disease associated with SARS-CoV-2, multisystem inflammatory syndrome in children (MIS-C), it is rare for kids to develop neurological post-COVID complications as part of MIS-C. Recently, a case report published in Neurology describes a two-year-old who developed multisystem inflammatory syndrome in children (MIS-C) with associated neurological complications (Abel et al., 2020). Of note, MIS-C presents in a similar …
Case Study of 8 COVID-19 Patients with Anti-SARS-CoV-2 Antibodies in CSF and Blood-Brain Barrier Disruption
A case series report published in Neurology: Neuroimmunology & Neuroinflammation describes eight COVID-19 patients with encephalopathy prolonged comatose or stuporous states (Alexopoulos et al., 2020). These patients were enrolled in the study from the ICU of the University Hospital in Athens, Greece and showed “signs of encephalopathy, including altered mental status, confusion, delirium, stupor, or coma, either before intubation or after sedation withdrawal when their respiratory status had improved.” There were 4 men and 4 women enrolled and they were between the ages of 57 and 84. None …
COVID-19-Associated Acute Necrotizing Encephalopathy with Neuronal Autoantibodies
A case study published earlier this summer describes COVID-19-associated acute necrotising encephalopathy with the presence of IgG reactive to cerebral fibers. Writing in J Neurol Neurosurg Psychiatry, Dalamarre et al. describe the case of a 51-year-old man without family history of neurological disease (Delamarre et al., 2020). After 10 days of fever and cough, he was hospitalized and diagnosed with COVID-19 via positive rtPCR and bilateral ground-glass opacities on chest CT. On day 12, he was admitted to the ICU for non-invasive ventilation and by this point, his neurological examination was …