Melamed Lab

Publications

  1. Al Ozonoff PhD*, Naresh Doni Jayavelu*, PhD, Shanshan Liu*, MPH, Esther Melamed, MD, PhD*, Carly E. Milliren, MPH^, Jingjing Qi, MS^, Linda N Geng, MD, PhD^, Grace A. McComsey, MD, Charles B. Cairns, MD, Lindsey R. Baden, MD, Joanna Schaenman, MD, PhD, Albert C. Shaw, MD, PhD, Hady Samaha, MD, Vicki Seyfert-Margolis,XX, Florian Krammer, PhD, Lindsey B. Rosen, PhD, Hanno Steen, PhD, Ravi Dandekar, XX, Casey Shannon, XX, Rafick Sekaly, PhD, Lauren I. R. Ehrlich, PhD, David Corry, MD, Farrah Kheradmand, MD, Mark A. Atkinson, PhD, Scott C. Brakenridge, MD, Nelson I Agudelo Higuita, MD, Jordan P. Metcalf, MD, Catherine L. Hough, MD, William B. Messer, MD, PhD, Bali Pulendran, PhD, Kari C. Nadeau, MD, PhD, Mark M Davis, PhD, Ana Fernandez Sesma, PhD, Viviana Simon, MD, PhD, David A. Hafler, MD, Ofer Levy, MD, PhD, Monica Kraft, MD, Chris Bime, MD, Elias K. Haddad, PhD, Carolyn S. Calfee, MD, David J. Erle, MD,  Bjoern Peters, PhD, Steven H. Kleinstein, PhD, Elaine F. Reed, PhD, Alison D. Augustine, PhD, Joann Diray-Arce, PhD, Holden T. Maecker, PhD, Matthew C. Altman, MD,  Ruth R. Montgomery, PhD, Patrice M.  Becker, MD, Nadine Rouphael, MD$, “Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.” Nature Communications, 2024   https://doi.org/10.1038/s41467-023-44090-5 ( *co-first author)
  1. Logue, E, Melamed E, Hilsabeck Robin, “A History Over-Represented in Women: The Association of Trauma, Stress, and Immune System Activation with Impaired Cognition and Dementia Risk,” in press, Clinical Neuropsychologist, 2024
  1. Aziz, R., Siles, N., Kelley, M. , Wylie, Melamed, E., Brode, W.,M (co-last authors) “Clinical Characteristics Of    Long Covid Patients Presenting To A Dedicated Academic Post-Covid-19 Clinic,” Scientific Reports. 2023 Dec 11;13(1):21971. doi: 10.1038/s41598-023-48502-w.
  1. Nadia Siles*, Maisey Schuler*, Cole Maguire, Dzifa Amengor, Annalee Nguyen, Rebecca Wilen, Jacob Rogers, Sam Bazzi, Blaine Caslin, Christopher DiPasquale, Melissa Abigania, Eric Olson, Janelle Creaturo, Kerin Hurley, Todd A Triplett, Justin F Rousseau, Stephen M Strakowski, Dennis Wylie, Jennifer Maynard, Lauren I R  Ehrlich, Esther Melamed medRxiv. 2023 Dec 7:2023.12.05.23299462. doi: 10.1101/2023.12.05.23299462. ( *co-first author)
  1. Cole Maguire, Elie Soloveichik, Netta Blinchevsky, Jaimie Miller, Robert Morrison, MD, FCCP, Johanna Busch,     MD, PhD, MPhil, W. Michael Brode, MD, Dennis Wylie, PhD, Justin Rousseau, MD, MMSc, FAMIA, Esther Melamed, MD PhD “Dissecting COVID-19 Outcomes:Multi-Organ Disease and a Role for Albumin,” medRxiv. 2023 Nov 27:2023.11.27.23297171. doi: 10.1101/2023.11.27.23297171.
  1. Kesler SR, PhD1,2, Rocha OYF, BSN, RN1, Schutz ADLT, BS1, Lewis, K RN, PhD1, Aziz RM3, Henneghan AM, RN, PhD1, Melamed E, MD, PhD3, W. Brode M, MD4, “Widespread functional and effective connectome dysconnectivity after mild to moderate COVID-19 infection is associated with lower cognitive outcomes,” Research Square, 2023 https://doi.org/10.21203/rs.3.rs-3466991/v1
  1. Gygi JP*, Maguire C*, Patel RK, Shinde P, Konstorum A, Shannon CP, Xu L, Hoch A, Jayavelu ND, Network I,Haddad EK, Reed EF, Kraft M, McComsey GA, Metcalf J, Ozonoff A, Esserman D, Cairns CB, Rouphael N, Bosinger SE, Kim-Schulze S, Krammer F, Rosen LB, van Bakel H, Wilson M, Eckalbar W, Maecker H, Langelier CR, Steen H, Altman MC, Montgomery RR, Levy O, Melamed E, Pulendran B, Diray-Arce J, Smolen KK, Fragiadakis GK, Becker PM, Augustine AD, Sekaly RP, Ehrlich LIR, Fourati S, Peters B, Kleinstein SH, Guan.  L.   Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants. bioRxiv. 2023 Nov 6:2023.11.03.565292. doi:  10.1101/2023.11.03.565292. (*co-first author)
  1. Bazzi, S.A.; Maguire, C.; Mayfield, R.D.; Melamed, E. “Alcohol induces concentration-dependent transcriptomic     changes in oligodendrocytes.” bioRxiv. 2023 Sep 22:2023.09.22.559075. doi: 10.1101/2023.09.22.559075
  1. Shi L, Rahman R, Melamed E, Gwizdka J, Rousseau JF, Ding Y. Using Explainable AI to Cross-Validate Socio-economic Disparities Among Covid-19 Patient Mortality.AMIA Jt Summits Transl Sci Proc. 2023 Jun 16;2023:477-486. eCollection 2023. PMID: 37350891; PMCID: PMC10283090.
  1. Ramasamy A*, Wang C*,  Brode WM, Verduzco-Gutierrez M,  Melamed E, “Acute and Post-acute Sequelae of  SARS-CoV-2 infection: Clinical Symptoms and Mechanisms of Disease,” Phys Med Rehabil Clin N Am. 2023 Aug;34(3):623-642. doi: 10.1016/j.pmr.2023.04.004. Epub 2023 Apr 11. ( *co-first author)
  1. Wang, C*.; Ramasamy, A*.; Verduzco-Gutierrez, M.; Brode, W. M.; Melamed, E., “Acute and Post acute Sequelae of SARS-CoV-2 infection: A Review of Risk Factors and Social Determinants,”Virol J. 2023 Jun 16;20(1):124. doi: 10.1186/s12985-023-02061-8 ( *co-first author)
  1. Melamed E*, Rydberg L*, Ambrose AF, Bhavaraju-Sanka R, Fine, JS, Fleming TK, Herman E, Phipps JL, Kucera JR, Longo M, Niehaus W, Oleson CV, Sampsel S, Silver J, Smith M, Verduzco-Gutierrez M, “Multi-Disciplinary collaborative consensus guidance statement on the assessment and treatment of neurologic sequelae in patients with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC),” PM&R Journal, 2023, 14(10):1270-1291 doi: 10.1002/pmrj.12894. ( *co-first author),
  1. Diray-Arce J, Fourati S, Doni Jayavelu N, Patel R, Maguire C, Chang AC, Dandekar R, Qi J, Lee BH, van Zalm P, Schroeder A, Chen E, Konstorum A, Brito A, Gygi JP, Kho A, Chen J, Pawar S, Gonzalez-Reiche AS, Hoch A, Milliren CE, Overton JA, Westendorf K; IMPACC Network; Cairns CB, Rouphael N, Bosinger SE, Kim-Schulze S, Krammer F, Rosen L, Grubaugh ND, van Bakel H, Wilson M, Rajan J, Steen H, Eckalbar W, Cotsapas C, Langelier CR, Levy O, Altman MC, Maecker H, Montgomery RR, Haddad EK, Sekaly RP, Esserman D, Ozonoff A, Becker PM, Augustine AD, Guan L, Peters B, Kleinstein SH., “Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients”, Cell Reports Medicine 2023 Jun 20;4(6):101079. doi: 10.1016/j.xcrm.2023.101079. 2023 May 23.  (Esther Melamed is a co-author as part of IMPACC Manuscript Writing Team and IMPACC Steering Commitee)
  1. Melamed E, Palmer J and Fonken C, Advantages and limitations of experimental autoimmune encephalomyelitis in breaking down the role of the gut microbiome in multiple sclerosis, Front Mol Neurosci. 2022 Nov 4;15:1019877. doi: 10.3389/fnmol.2022.1019877. eCollection 2022.
  1. Bazzi S A, Maguire C, Holay N, Geltman J, Hurley K,  DiPasquale C,  Abigania M, Masters E O, Ehrlich L I R, Triplett T A, Melamed E, Longitudinal COVID-19 immune trajectories in patients with neurological autoimmunity on anti-CD20 therapy, Mult Scler Relat Disord. 2022 Dec;68:104195. doi: 10.1016/j.msard.2022.104195. Epub 2022 Sep 26.
  1. Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau KC, Davis MM, Hough CL, Messer WB, Higuita NIA, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N, Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau KC, Davis MM, Hough CL, Messer WB, Higuita NIA, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N. Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study. 2022 Sep;83:104208. doi: 10.1016/j.ebiom.2022.104208.
  1. IMPACC Manuscript Writing Team; IMPACC Network Steering Committee, “Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study,” Sci Immunol. 2021 Aug 10;6(62):eabf3733. doi: 10.1126/sciimmunol.abf3733.
  1. Caslin B, Mohler K, Thiagarajan S, Melamed E, Alcohol as Friend or Foe in Autoimmune Diseases: a Role for Gut Microbiome? Gut Microbes. 2021 Jan-Dec;13(1):1916278. doi: 10.1080/19490976.2021.1916278.
  1. Li J, Bazzi S,  Schmitz F,  Tanno H,  McDaniel JR, Lee CH,  Joshi C,  Kim JE,  Monson N, Greenberg BM, Hedfalk K, Melamed E, and  Ippolito, GC (corresponding authors), Molecular Level Characterization of Circulating Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder, Neurol Neuroimmunol Neuroinflamm. 2021 Jun 24;8(5):e1034. doi: 10.1212/NXI.0000000000001034. Print 2021 Jul.
  1. Roberto Alejandro Cruz, Nick Hogan, Jayne Sconzert, Megan Sconzert, Eugene O Major, Robert P Lisak, Esther Melamed, Thomas C Varkey, Ethan Meltzer, Andrew Goodman, Oleg Komogortsev, Matthew S Parsons, Kathleen Costello, Jennifer S Graves, Scott Newsome, Scott S Zamvil, Elliot M Frohman, Teresa C Frohman, Treating MS after surviving PML: Discrete strategies for rescue, remission, and recovery patient 2: From the National Multiple Sclerosis Society Case Conference Proceedings, Neurology® Neuroimmunology & Neuroinflammation, 2021 doi: 1212/NXI.0000000000000930
  1. Ochi, MGS,  Shapiro, SC, Melamed E, “Lupus and NMOSD: The Blending of Humoral Autoimmunity,” Case Reports in Rheumatology, 2020 https://doi.org/10.1155/2020/8820071
  1. Maguire C, Frohman T, Zamvil S, Frohman E, Melamed E, “Should interferons take front stage as an essential MS disease-modifying therapy in the era of coronavirus disease 2019?” Neurol Neuroimmunol Neuroinflamm 2020 doi: 1212/NXI.0000000000000811
  1. Frohman, E, Villemarette-Pittmand, N Melamed, E, Cruz RA, Longmuire, R, Varkey TC, Steinman L, Zamvil SS, Frohman, T, “Part I. SARS-CoV-2 triggered ‘PANIC’1 attack in severe COVID-19,” Journal of the Neurological Sciences 2020 https://doi.org/10.1016/j.jns.2020.116936
  1. Melamed E and Lee M, “Multiple Sclerosis and Cancer: the Ying Yang Effect of Disease Modifying Therapies,” Frontiers in Immunology, Frontiers Immunology, 2020 (>33K views Feb 2022, top 2% of Frontiers Immunology articles) https://doi.org/10.3389/fimmu.2019.02954
  1. Silvia Tenembaum, E Yeh, Hesham Abboud, Raed Alroughani, Ayse Altintas, Lilyana Amezcua, Metha Apiwattanakul, Nasrin Asgari, Brenda Banwell, Jeffrey Bennett, Denis Bichuetti, Terrence F Blaschke, James Bowen, Alexey Boyko, Alexander Brandt, Simon Broadley, Wolfgang Brück, Edgar Carnero Contentti, Robert Carruthers, Tanuja Chitnis, Jeffrey Cohen, Guillermo Delgado-García, Irena Dujmovic Basuroski, Nikos Evangelou, Kazuo Fujihara, Andrew Goodman, Benjamin Greenberg, May Han, Joachim Havla, Kerstin Hellwig, Jyh Yung Hor, Raffaele Iorio, Anu Jacob, Sven Jarius, Jorge Andres Jimenez Arango, Ilana Katz Sand, Kim Ho Jin, Kim Sung Min, Dorlan Kimbrough, Najib Kissani, Eric Klawiter, Ingo Kleiter, Marco Lana-Peixoto, Maria Isabel Leite, Michael Levy, Yaou Liu, Fred Lublin, Youssoufa Maiga, Yang Mao-Draayer, Romain Marignier, Sara Mariotto, Marcelo Matiello, Esther Melamed, Callene Momtazee, Ichiro Nakashima, Jayne Ness, Celia Oreja-Guevara, Jacqueline Palace, Lekha Pandit, Friedemann Paul, Sarah Planchon Pope, Pröbstel Anne-Katrin, Peiqing Qian, Chao Quan, Pavle Repovic, Claire Riley, Marius Ringelstein, Dalia Rotstein, Charité Klemens Ruprecht, Sá Maria José, Albert Saiz, Douglas Sato, Eslam Shosha, Nancy Sicotte, Sasitorn Siritho, Aksel Siva, Terry J Smith, Ibis Soto, Silva Tenembaum, Leticia Tornes, Pablo Villoslada, Dean Wingerchuk, Jens Wüfel, Bassem Yamout, Michael R Yeaman, E Ann Yeh, Scott Zamvil, Guthy-Jackson Foundation International Clinical Consortium,Pediatric NMOSD: a review and position statement on approach to work-up and diagnosis, Frontiers in Pediatrics, 2020 https://doi.org/10.3389/fped.2020.00339
  1. Caslin B*, Maguire C*, Karmakar A, Mohler K, Wylie D, Melamed E, “Moderate Alcohol Shifts Gut Microbial Networks and Ameliorates Disease in a Sex-Specific Pattern in a Murine Model of Neuroinflammation,” Proceedings of National Academy of Science, 2019 (24 citations as of 2/2022) https://doi.org/10.1073/pnas.1912359116 ( *co-first author)
  1. Perrone C, Lisak RP, Meltzer E, Sguigna P, Melamed E, Lucas A, Freeman L, Pardo G, Goodman A, Frohman TC, Costello K, Zamvil SS, Frohman EM, “Cataclysmic Neurologic Presentation in a SLE Patient on Immune Suppression,” Neurol Neuroimmunol Neuroinflamm, 2019 DOI: https://doi.org/10.1212/NXI.0000000000000582
  1. Bradshaw M, Lisak R, Meltzer E, Melamed E, Lucas A, Freeman L, Frohman TC,  Costello K, Balcer L, Galetta S, Chitnis T,  Zamvil SS,  and Frohman EM “A young man ‘in trouble’ with acute hallucinations, ocular motor deficits and facial weakness,” Neurol Neuroimmunol Neuroinflamm, 2019 doi: 1212/NXI.0000000000000526
  1. Romero A, Lisak R, Meltzer E, Fox E, Melamed E, Lucas A, Freeman L, Frohman TC, Costello K, Zamvil SS, Frohman EM, Gelfand JM.“A young man with numbness in arms and legs ” Neurology and Neuroinflammation, 2018 DOI: https://doi.org/10.1212/NXI.0000000000000509
  1. Melamed E,  Levy M,  Waters P, Kazutoshi Sato D,  Bennett JL, John GR,  Hooper DC, Saiz A, Bar-Or A, Kim HL, Pandit L, Leite MI, Asgari N, Kissani N, Hintzen R, Marignier R, Jarius S, Marcelletti J, Smith TJ,  Yeaman MR, and Han MH, “Update on Biomarkers in Neuromyelitis Optica,” Neurol Neuroimmunol Neuroinflamm. 2015 Aug; 2(4): e134 DOI: https://doi.org/10.1212/NXI.0000000000000134
  1. Melamed E and Arnold AP, The Role of LINEs and CpG islands in Dosage Compensation in the Chicken Genome, Chromosome Res. 2009 Aug 12. doi: 1007/s10577-009-9068-4
  1. Melamed E, Elashoff D, Arnold AP, Evaluating dosage compensation on the chicken Z chromosome: should effective dosage compensation eliminate sexual bias?, Heredity. 2009 Aug 12. DOI: 1038/hdy.2009.91
  1. Melamed E, Wyatt LE (co-first authors), Padilla T, and Ferry RJ, Patient-Based Cultural Competency Curriculum for Pre-Health Professionals, Fam Med. 2008 Nov-Dec;40(10):726-33. https://pubmed.ncbi.nlm.nih.gov/18979261/
  1. Arnold AP, Itoh Y, Melamed E. A bird’s eye view of sex chromosome dosage compensation.  Annual Review of Genomics and Human Genetics 2008. 9:109-27. DOI: 1146/annurev.genom.9.081307.164220
  1. Melamed E and Arnold AP Regional dosage compensation in the MHM valley of the chicken Z chromosome, Genome Biol. 2007 Sep 27;8(9):R202 https://doi.org/10.1186/gb-2007-8-9-r202
  1. Itoh Y and  Melamed E (co-first authors), Yang X, Kampf K, Wang S, Yehya N, Van Nas A, Replogle K, Band M, Clayton D, Schadt EE,  Lusis AJ, and Arnold AP Dosage compensation is less effective in birds than in mammals J Biol. 2007, 6:3. Highly Accessed doi: 1186/jbiol53
  1. Luo M, Yu Y, Kim H, Kudrna D, Itoh Y, Agate RJ, Melamed E, Goicoechea JL, Talag J, Mueller C, Wang W, Currie J, Sisneros NB, Wing RA, Arnold AP.Utilization of a zebra finch BAC library to determine the structure of an avian androgen receptor genomic region. Genomics. 2006 Jan;87(1) https://doi.org/10.1016/j.ygeno.2005.09.005

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