The Agilent SuperNova has both Mo and Cu microfocus X-ray tubes with an Rigaku Oxford Diffraction HyPix6000E pixel array detector and an Oxford Cryostream 700 low temperature device. The Agilent, using the Cu source, provides a very intense, highly focused X-ray beam. Using the Cu source, the absolute structure of crystals containing light atom organic molecules can be determined. In many instances, there is no need to synthesize a heavy atom derivative or attach a group with a known absolute center to determine absolute stereochemistry. Additionally, because of the bright X-ray source, very small, poorly diffracting samples that are unsuitable for analysis using the conventional sealed tube sources can often yield publication quality structures. The Oxford 700 series Cryostream can provide stable temperature ranging from 100 to 400 K. With the large AtlasS2 CCD detector, the SuperNova can be used to collect bulk sample powder diffraction data at the same temperature that the single crystal data was collected, which makes the unit cell comparisons more appropriate.