Aoshu Zhong

Aoshu ZhongDegree: B.S., Wuhan University

Entered Group: Fall, 2012 (Chemical Biology and Medicinal Chemistry program)

Research Projects: Mechanistic Studies of Reactions Catalyzed by B12-dependent Radical SAM Enzymes

Group Publications:

Lin, C.-I.; Sasaki, E.; Zhong, A.; Liu, H.-w. “In Vitro Characterization of LmbK and LmbO: Identification of GDP-D-erythro-α-D-gluco-octose as a Key Intermediate in Lincomycin A Biosynthesis.” J. Am. Chem. Soc. 2014, 136, 906-909.

Bridwell-Rabb, J.; Kang, G.; Zhong, A.; Liu, H.-w.; Drennan, C. L. “An HD-Domain Phosphohydrolase Active Site Tailored for Oxetanocin-A Biosynthesis.” Proc. Natl. Acad. Sci. USA. 2016, 113, 13750-13755.

Bridwell-Rabb, J.; Zhong, A.; Drennan, C. L.; Liu, H.-w. “A B12-dependent Radical SAM Enzyme Involved in Oxetanocin A Biosynthesis.” Nature 2017, 544, 322-326.

Ruszczycky, M. W.; Zhong, A.; Liu, H.-w. “Following the Electrons: Peculiarities in the Catalytic Cycles of Radical SAM Enzymes.” Nat. Prod. Rep. 2018, 35, 615-621.