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Liu Lab

The University of Texas at Austin College of Pharmacy

2009-2007

  1. Ogasawara, Y.; Liu, H.-w. “Biosynthetic Studies of Aziridine Formation in the Azicemicins.” J. Am. Chem. Soc. 2009, 131, 18066-18068.
  2. Tao, Z.; Gao, P.; Liu, H.-w. “Studies of the Expression of Human Poly(ADP-ribose) Polymerase-1 inSaccharomyces cerevisiae and Identification of PARP-1 Substrates by Yeast Proteome Microarray Screening.”Biochemistry 2009, 48, 11745-11754.
  3. Tao, Z.; Gao, P.; Liu, H.-w. “Identification of ADP-Ribosylation Sites in the PARP-1 Automodification Domain: Analysis and Implications.” J. Am. Chem. Soc. 2009, 131, 14258-14260.
  4. Szu, P.; Ruszczucky, M.; Choi, S. H.; Yan, F.; Liu, H.-w. “Characterization and Mechanistic Studies of DesII: A Radical S-Adenosylmethionine Enzyme Involved in the Biosynthesis of TDP-D-Desosamine.” J. Am. Chem. Soc. 2009, 131, 14030-14042.
  5. Thibodeaux, C. J.; Liu, H.-w. “Unraveling the Mechanisms of Isoprenoid Biosynthetic Enzymes: Mechanistic Studies of the Early Stage Enzymes.” Chimia 2009, 63, 334-339.
  6. White, J. A.; Thibodeaux, C. J.; Liu, H.-w. “Enzymatic Synthesis of TDP-sugars.” Meth. Enzymol. 2009, 459, 521-544.
  7. Munos, J. W.; Pu, X.; Manssorabadi, S. O.; Kim, H. J.; Liu, H.-w. “A secondary Kinetic Isotope Effect Study of 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase-catalyzed Reaction: Evidence for a Retroaldol-Aldol Rearrangement.” J. Am. Chem. Soc., 2009, 131, 2048-2049.
  8. Thibodeaux, C. J.; Melancon, C. E., III.; Liu, H.-w. “Natural Product Sugar Biosynthesis and Enzymatic Glycodiversification.” Angew. Chem. Int. Ed., 2008, 47, 9814-9859.
  9. Munos, J. W.; Moon, S.-J.; Manssorabadi, S. O.; Chang, W.-c.; Hong, L.; Yang, Y.; Liu, A.; Liu, H.-w. “Purification and Characterization of the Epoxidase Catalyzing the Formation of Fosfomycin fromPseudomonas syringae.” Biochemistry, 2008, 47, 8726-8735.
  10. Smith, P.; Szu, P.-H.; Bui, C.; Liu, H.-w.; Tsai, S.-C. “Structure and Mutagenic Retroevolution of the E1 Dehydrase: at the Cross Road of Dehydration, Aminotransferation and Racemization.” Biochemistry, 2008,47, 6329-6341.
  11. Mirica, L. M.; McCusker, K. P.; Munos, J. W.; Liu, H.-w.; Klinman, J. P. “18O Kinetic Isotope Effects in Non-Heme Iron Enzymes: Probing the Nature of Fe/O2 Intermediates.” J. Am. Chem. Soc., 2008, 130, 8122-8123.
  12. Borisova, S.; Kim, H. J.; Pu, X.; Liu, H.-w. “Glycosylation of Acyclic and Cyclic Aglycone Substrates by Macrolide Glycosyltransferase DesVII/DesVIII: Analysis and Implications.” ChemBioChem, 2008, 9, 1554-1558.
  13. Tao, Z.; Gao, P.; Hofmann, D.; Liu, H.-w. “Domain C of Human Poly(ADP-ribose) Polymerase-1 is Important for Enzyme Activity and Contains a Novel Zinc-Ribbon Motif.” Biochemistry, 2008, 47, 5804-5813.
  14. Liautard, V.; Desvergnes, V.; Itoh, K.; Liu, H.-w.; Martin, O. R. “Convergent and Stereoselective Synthesis of Iminosugar-containing Galf and UDP-Galf Mimics. Evaluation as Inhibitors of UDP-Gal Mutase.” J. Org. Chem. 2008, 73, 3103-3115.
  15. Hong, L.; Zhao, Z.; Melan�on, C. E., III; Zhang, H.; Liu, H.-w. “In Vivo Characterization of the Enzymes Involved in TDP-D-Forosamine Biosynthesis in the Spinosyn Pathway of Saccharopolyspora spinosa.” J. Am. Chem. Soc. 2008, 130, 4954-4967.
  16. Yuan, Y.; Bleile, D. W.; Wen, X.; Sanders, D. A. R.; Itoh, K.; Liu, H.-w.; Pinto, B. M. “Investigation of Binding of UDP-Galf and UDP-[3-F]Galf to UDP-galactopyranose Mutase by STD-NMR Spectroscopy, and Molecular Dynamics, and CORCEMA-ST Calculations.” J. Am. Chem. Soc. 2008, 130, 3157-3168.
  17. Munos, J. W.; Pu, X.; Liu, H.-w. “Synthesis and Analysis of a Fluorinated Product Analogue as an Inhibitor for 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase.” Bioorg. Med. Chem. Lett. 2008, 16, 3090-3094.
  18. Thibodeaux, C. J.; Mansoorabadi, S. O.; Kittleman, W.; Chang, W.-c.; Liu, H.-w. “Evidence for the Involvement of Acid/Base Chemistry in the Reaction Catalyzed by the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase (IDI-2) from Staphylococcus aureus.” Biochemistry 2008,47, 2547-2558.
  19. Thibodeaux, C.; Liu, H.-w.; Thorson, J. S. “Complimentary Routes to Natural Product Glycodiversification: Pathway Engineering and Glycorandomization.” In Comprehensive Glycoscience, (Kamerling, J. P., Boons, G.-J., Lee, Y., Suzuki, A., Taniguchi, N., Voragen, A. G. J., Eds.) Elsevier: Amsterdam; 2007, Vol 3, p. 373-396.
  20. Takahashi, H.; Liu, H.-w. “Biosynthesis of Mycarose.” Kagaku to Seibutsu (Chemistry & Biology in Japanese)2007, in press.
  21. Kittleman, W.; Thibodeaux, C. J.; Liu, Y.-n.; Zhang, H.; Liu, H.-w. “Characterization and Mechanistic Studies of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase from Staphylococcus aureus.“Biochemistry 2007, 46, 8401-8413.
  22. Zhang, H.; White-Phillip, J. A.; Melan�on, C. E. III; Yu, W.-l.; Kwon, H.-j.; Liu, H.-w. “Biosynthetic Studies of Kijanimicin Provide Insights into Unusual Sugar Biosynthesis and Spirotetronate Formation.” J. Am. Chem. Soc. 2007, 129, 14670-14683.
  23. Thibodeaux, C. J.; Melancon, C. E.; Liu, H.-w. “Understanding and Exploiting Sugar Biosynthetic Enzymes and Natural Product Glycosyltransferases.” Nature 2007, 446, 1008-1016.
  24. Kim, H. J.; Pongdee, R.; Wu, Q.; Hong, L.; Liu, H.-w. “Studies of the Biosynthesis of Spinosyn inSaccharopolyspora spinosa: Synthesis of the Cross-Bridging Precursor and Elucidation of the Biological Role of SpnJ.” J. Am. Chem. Soc. 2007, 129, 14582-14584.
  25. Yan, F.; Moon, S.-J.; Liu, P.; Zhao, Z.; Lipscomb, J. D.; Liu, A.; Liu, H.-w. “Determination of the Substrate Binding Mode to the Active Site Iron of (S)-2-Hydroxypropylphosphonic Acid Epoxidase Using 17O-Enriched Substrates and Substrate Analogues.” Biochemistry 2007, 46, 12628-12638.
  26. Desvergnes, S.; Desvergnes, V.; Martin, O. R.; Itoh, K.; Liu, H.-w.; Py, S. “Stereoselective Synthesis of β-1-C-Substituted 1,4-Dideoxy-1,4-Imino-D-Galactitols and Evaluation as UDP-Galactopyranose Mutase Inhibitors.” Bioorg. Med. Chem. 2007, 15, 6443-6449.
  27. Mansoorabadi, S. O.; Thibodeaux, C. J.; Liu, H.-w. “The Diverse Roles of Flavin Coenzymes – Nature’s Most Versatile Thespians.” J. Org. Chem. 2007, 72, 6329-6342.
  28. Wu, Q.; Liu, Y.-n.; Chen, H.; Molitor, E. J.; Liu, H.-w. “A Retro-Evolution Study of CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1): Implications for C-3 Deoxygenation in the Biosynthesis of 3,6-Dideoxyhexoses.” Biochemistry 2007, 46, 3759-3767.
  29. Melancon, C. E.; Liu, H.-w. “Engineered Biosynthesis of Macrolide Antibiotics Bearing the Non-Natural Deoxysugars 4-epi-D-mycaminose and 3-N-Monomethylamino-3-deoxy-D-fucose.” J. Am. Chem. Soc. 2007,129, 4896-4897.
  30. Thibodeaux, C. J.; Liu, H.-w. “Manipulating Nature’s Sugar Biosynthetic Machineries for Glycodiversification of Macrolides: Recent Advances and Future Prospects.” Pure Appl. Chem. 2007, 79, 785-799.
  31. Melancon, C. E.; Hong, L.; White, J. A.; Takahashi, H.; Liu, Y.-n.; Liu, H.-w. “Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-isomerase (Tyl1a) from the TDP-D-Mycaminose Pathway of Streptomyces fradiae.” Biochemistry 2007, 46, 577-590.
  32. Itoh, K.; Huang, Z.; Liu, H.-w. “Synthesis and Analysis of a Substrate Analogue for UDP-Galactopyranose Mutase: Implication for an Oxocarbenium Intermediate in the Catalysis.” Org. Lett. 2007, 9, 879-882.