UT Shield

Liu Lab

The University of Texas at Austin College of Pharmacy

2024-2022

  1. Fan, P.-H.; Sato, S.; Yeh, Y.-C.; Liu, H.-w. “Biosynthetic Origin of the Octose Core and Its Mechanism of Assembly during Apramycin Biosynthesis.” J. Am. Chem. Soc. 2023, 145, in revision.
  2. Lee, Y.-H.; Yeh, Y.-C.; Fan, P.-H.; Zhong, A.; Ruszczycky, M. W.; Liu, H.-w. “Changing Fates of the Substrate Radicals Generated in the Active Sites of the B12-dependent Radical SAM Enzymes OxsB and AlsB.” J. Am. Chem. Soc. 2023, 145, 3656-3664. [PMC9940012]
  3. Lee, Y-H.; Re, D.; Jeon, B-s.; Liu, H.-w. “S-Adenosylmethionine: More than Just a Methyl Donor.” Nat. Prod. Rep. 2023, in press. [NIHMSID1875589]
  4. Fan, P.-H.; Geng, Y.; Romo, A. J.; Zhong, A.; Zhang, J.; Yeh, Y.-C.; Lee, Y.-H.; Liu, H.-w. “Two Radical SAM Enzymes are Necessary and Sufficient for the In Vitro Production of the Oxetane Nucleoside Antiviral Agent Albucidin.” Angew. Chem. Int. Ed. 2022, 61, e202210362. [PMC9561071]
  5. Chen, Z.; Sato. S.; Geng. Y., Zhang, J.; Liu, H.-w. “Identification of the Early Steps in Herbicidin Biosynthesis Reveals an Atypical Mechanism of C-Glycosylation.” J. Am. Chem. Soc. 2022, 144, 15653-15661. [PMC9462585]
  6. De, B. C.; Zhang, W.; Yang, C.; Mándi, A.; Huang, C.; Zhang, L.; Liu, W.; Ruszczycky, M. W.; Zhu, Y.; Ma, M.; Bashiri, G.; Kurtán, T.; Liu, H.-w.; Changsheng Zhang, C. “Flavin-Enabled Reductive and Oxidative Epoxide Ring Opening Reactions.” Nature Commu. 2022, 11, 1-13.
  7. Ren, D.; Lee, Y.-H.; Wang, S.-A.; Liu, H.-w. “Characterization of the Oxazinomycin Biosynthetic Pathway Revealing the Key Role of a Non-heme Iron-dependent Monooxygenase.” J. Am. Chem. Soc. 2022, 144, 10968-10977. [PMC9233086]
  8. Zhang, J.; Hou, X.; Chen, Z.; Ko, Y.; Ruszczycky, M. W.; Chen, Y.; Zhou, J,; Liu, H.-w. “Dioxane Bridge Formation in the Biosynthesis of Spectinomycin Involves a Twitch Radical SAM Dehydrogenase that Appears to Have Evolved from an Epimerase.” J. Am. Chem. Soc. 2022, 144, 9910-9919. [PMC9204835]
  9. Lin, W.-L.; Chen, J.-K.; Wen, X.; He, W.; Zarceno, G. A.; Chen, Y.; Paull, T.; Liu, H.-w. ” DDX18 Prevents R-loop-Induced DNA Damage and Genome Instability via PARP-1.” Cell Reports, 2022, 40 (July), 111089.
  10. Lee, Y.-H.; Hou, X.; Chen, R.; Feng, J.; Liu, X.; Ruszczycky, M. W.; Guo, J.-M.; Wang, B.; Zhou, J.; Liu, H.-w. “Radical S-Adenosyl Methionine Enzyme BlsE Catalyzes a Radical Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S.” J. Am. Chem. Soc. 2022, 144, 4478-4486.[PMC8934444]
  11. Lee, Y.-H.; Liu, H.-w. “Studies of GenK and OxsB, Two B12-Dependent Radical SAM Enzymes Involved in Natural Product Biosynthesis.” Meth. Enzymol. 2022, 677, 71-90. [NIHMSID1788471]
  12. Chen, T.-Y.; Zheng, Z.; Zhang, X.; Chen, J.; Cha, L.; Tang, Y.; Guo, Y.; Zhou, J.; Wang, B.; Liu, H.-w.; Chang, W.-c. “Decipher Reaction Pathway of Mononuclear Iron Enzymes Catalyzed N-C Triple Bond Formation in Isocyanide Lipopeptides and Polyketides Biosynthesis.” ACS Catalysis 2022, 12, 2270-2279. [NIHMS1778719]
  13. Jeon, B.-s.; Huang, T.-Y.; Ruszczycky, M. W.; Choi, S.-h.; Kim, N.; Franklin, J. L.; Hung, S.-C.; Liu, H.-w. “Byproduct Formation During the Biosynthesis of Spinosyn A and Evidence for an Enzymatic Interplay to Prevent its Formation.” Tetrahedron2022, 103, 132569. (invited article for special issue honoring Prof. Steve Martin) [PMC9175908]